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[蛋白质 - 热量不足对新皮质突触联系影响的特征]

[Characteristics of the effect of protein-calorie insufficiency on synaptic contacts in the neocortex].

作者信息

Medvedev D I, Babichenko I I

出版信息

Biull Eksp Biol Med. 1988 Apr;105(4):494-7.

PMID:3129044
Abstract

The quantitative ultrastructural study of changes in neocortical synaptic junctions were performed in undernourished adult and developing mice. The results obtained indicate that sectional area of the terminals occupied by synaptic vesicles; synaptic cleft width and postsynaptic membrane thickness significantly decrease in undernourished animals. Sectional area of the terminals significantly decreases in young undernourished mice and increases in adult ones. At the same time, the degree of spine apparatus destruction increases and the number of cisterns decreases in both groups of undernourished animals.

摘要

对营养不良的成年和发育中小鼠的新皮质突触连接变化进行了定量超微结构研究。获得的结果表明,在营养不良的动物中,被突触小泡占据的终末截面积、突触间隙宽度和突触后膜厚度显著减小。终末截面积在幼年营养不良小鼠中显著减小,而在成年小鼠中增大。同时,两组营养不良动物的棘器破坏程度增加,池的数量减少。

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