Mizuno K, Yagi A, Satoi S, Takada M, Hayashi M
J Antibiot (Tokyo). 1977 Apr;30(4):297-302. doi: 10.7164/antibiotics.30.297.
Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including theonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity. Aculeacin A has relatively low toxicity in mice.
刺孢曲菌素A是从棘孢曲霉M-4214的菌丝饼中分离出的一种新型抗真菌抗生素。该抗生素为白色无定形粉末，可溶于低级醇类，几乎不溶于其他有机溶剂或水。刺孢曲菌素A经酸水解后产生棕榈酸和5种茚三酮阳性产物，包括苏氨酸、羟脯氨酸。该抗生素对霉菌和酵母菌显示出强效活性，但无抗菌活性。刺孢曲菌素A对小鼠的毒性相对较低。
