Abdelhamid Elkhansa, Awad Abdelmoneim, Gismallah Abdellatif
Department of Pharmacology, Faculty of Pharmacy, University of Khartoum ( Sudan ).
Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University . Safat ( Kuwait ).
Pharm Pract (Granada). 2008 Jan;6(1):25-32. doi: 10.4321/s1886-36552008000100005. Epub 2008 Mar 10.
To implement and assess hospital-based pharmaceutical care services for patients with asthma.
A prospective, randomized, controlled study was conducted in Shaab teaching hospital, Khartoum, Sudan. Patients were allocated randomly either in the intervention group (60) or control group (40) patients. The drug therapy of asthma for the patients in the intervention group was reviewed by a trained pharmacist, and interventions were suggested to the attending physicians for the identified problems. Intervention patients received comprehensive medication counselling and asthma education every 2 weeks, while the control group received the routine medical consultation and dispensing services. The outcome measures were recorded using structured forms at baseline and monitored during a follow-up of every two weeks for 6 months in both groups. Data were analyzed using SPSS version 13, level of significance was p<0.05.
At the end of the study period the mean reduction in frequency of acute attacks (1.91; SD=0.18 vs. 1.0; SD=0.14; p=0.03), nocturnal asthma symptoms (3.5; SD=0.3 vs. 1.1; SD=0.2; p=0.02) and frequency of using inhaled β2 agonists per week (19.9; SD= 2.1 vs. 3.3; SD=0.3; p=0.01) were significantly greater in the intervention group compared to control. A significant mean reduction (p=0.002) in the days of sickness/week was in the intervention group, while in control group there was an increase in mean days of sickness/week. The intervention group showed a significant greater improvement in the score for assessing the inhalation technique (p<0.001), patient's knowledge about asthma (p<0.001), and its drug-therapy (p=0.01) compared with control.
The present findings suggest that pharmacist's intervention can have positive impact on asthma-related outcomes in patients.
为哮喘患者实施并评估基于医院的药学服务。
在苏丹喀土穆的沙阿卜教学医院进行了一项前瞻性、随机、对照研究。患者被随机分配到干预组（60例）或对照组（40例）。由一名经过培训的药剂师对干预组患者的哮喘药物治疗进行评估，并就发现的问题向主治医生提出干预建议。干预组患者每两周接受一次全面的用药咨询和哮喘教育，而对照组接受常规医疗咨询和配药服务。在基线时使用结构化表格记录结局指标，并在两组中每两周随访一次，持续6个月进行监测。使用SPSS 13版软件进行数据分析，显著性水平为p<0.05。
在研究期结束时，与对照组相比，干预组在急性发作频率（1.91；标准差=0.18对1.0；标准差=0.14；p=0.03）、夜间哮喘症状（3.5；标准差=0.3对1.1；标准差=0.2；p=0.02）以及每周使用吸入性β2激动剂的频率（19.9；标准差=2.1对3.3；标准差=0.3；p=0.01）方面的平均降低幅度显著更大。干预组的每周患病天数平均显著减少（p=0.002），而对照组的每周患病天数平均有所增加。与对照组相比，干预组在评估吸入技术得分（p<0.001）、患者对哮喘的知晓度（p<0.001）及其药物治疗（p=0.01）方面的改善显著更大。
目前的研究结果表明，药剂师的干预可对患者的哮喘相关结局产生积极影响。
