Vozza Iole, Caldarazzo Vito, Polimeni Antonella, Ottolenghi Livia
Department of Oral and Maxillo-facial Sciences, "Sapienza" University of Rome, Rome, Italy.
Int Dent J. 2015 Feb;65(1):45-8. doi: 10.1111/idj.12133. Epub 2014 Sep 2.
The aim of this study was to evaluate periodontal status after periodontal treatment in patients with different malignant solid tumours submitted to chemotherapy.
Fifty-four patients with newly diagnosed early-stage solid tumour malignancy treated by surgery and eligible for adjuvant chemotherapy were enrolled in this study. Clinical periodontal parameters obtained by a single calibrated examiner were evaluated before chemotherapy (T0), 21 days after chemotherapy (T1) and 210 days after chemotherapy (T2). Patients were grouped into healthy or periodontally diseased subjects. All patients received oral hygiene instructions, and the diseased patients received periodontal treatment at baseline. Comparisons between the groups were performed using the McNemar test (P>0.05) and the Wilcoxon test with Bonferroni correction (P<0.02) using spss software.
Of 54 patients enrolled in the study, two did not present to the third assessment (T2). The prevalence of periodontitis was 35.2% at baseline and no significant difference was found in the follow-up assessments. There was a statistically significant reduction in probing depth (PD), plaque index (PI) and bleeding on probing (BOP) between baseline and follow-up assessments. The attachment level (AL) did not vary significantly between the different follow-up periods (P≥0.06).
Periodontal treatment was effective in reducing PI, BOP and PD and in maintaining AL in periodontitis cancer patients undergoing chemotherapy.
本研究旨在评估接受化疗的不同恶性实体肿瘤患者牙周治疗后的牙周状况。
本研究纳入了54例新诊断为早期实体肿瘤恶性肿瘤且接受手术治疗并适合辅助化疗的患者。由单一经过校准的检查者获取的临床牙周参数在化疗前（T0）、化疗后21天（T1）和化疗后210天（T2）进行评估。患者被分为健康或牙周疾病患者组。所有患者均接受口腔卫生指导，患病患者在基线时接受牙周治疗。使用SPSS软件，采用McNemar检验（P>0.05）和经Bonferroni校正的Wilcoxon检验（P<0.02）进行组间比较。
在纳入研究的54例患者中，有2例未参加第三次评估（T2）。基线时牙周炎患病率为35.2%，随访评估中未发现显著差异。基线和随访评估之间，探诊深度（PD）、菌斑指数（PI）和探诊出血（BOP）有统计学显著降低。不同随访期之间附着水平（AL）无显著变化（P≥0.06）。
牙周治疗对于接受化疗的牙周炎癌症患者在降低PI、BOP和PD以及维持AL方面是有效的。
