炎症标志物：CPAP 治疗轻度症状性 OSA 的 MOSAIC 随机试验数据。
Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA.
机构信息
Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland.
出版信息
Thorax. 2015 Feb;70(2):181-2. doi: 10.1136/thoraxjnl-2014-205958. Epub 2014 Sep 2.
UNLABELLED
The Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular (MOSAIC) trial compared 6 months of CPAP therapy, versus no CPAP, in 391 patients with minimally symptomatic obstructive sleep apnoea (OSA). We now report some exploratory outcomes, markers of systemic inflammation (interleukin 6 (IL-6), IL-10, C reactive protein, tumour necrosis factor). We found no consistent changes (all p values >0.13).
TRIAL REGISTRATION NUMBER
ISRCTN 34164388.
未加标签
多中心阻塞性睡眠呼吸暂停干预心血管（MOSAIC）试验比较了 391 例轻度症状性阻塞性睡眠呼吸暂停（OSA）患者 6 个月的 CPAP 治疗与无 CPAP 治疗。我们现在报告一些探索性结果，即全身炎症标志物（白细胞介素 6（IL-6）、IL-10、C 反应蛋白、肿瘤坏死因子）。我们没有发现一致的变化（所有 p 值均>0.13）。
试验注册号
ISRCTN34164388。
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