Gray J, Nicholson J K, Creasy D M, Timbrell J A
Toxicology Unit, School of Pharmacy, Birkbeck College, University of London, UK.
Arch Toxicol. 1990;64(6):443-50. doi: 10.1007/BF01977625.
A single dose of cadmium chloride (3.23 mumol Cd2+/kg) causing acute testicular damage in male rats also caused significant creatinuria and creatinaemia at 48 h after dosing. Doses of cadmium which did not cause testicular necrosis did not cause creatinuria or creatinaemia. Surgical ligation of the pampiniform plexus also caused ischaemic necrosis of the testis and this was followed by significant creatinuria and creatinaemia. However, neither orchidectomy followed by a toxic dose of cadmium, orchidectomy alone nor sham operation caused significant creatinuria or creatinaemia. Cadmium dosing induced a temporary loss of body weight which was less than that caused by food restriction. Food restriction did not cause significant creatinuria but did cause significant creatinaemia. These data suggest that the creatine is derived from the damaged testis and that measurement of urinary creatine may be a useful non-invasive means of detecting acute testicular damage caused by exposure to chemicals or mechanical impairment of blood flow.
单剂量氯化镉（3.23微摩尔Cd2+/千克）可导致雄性大鼠急性睾丸损伤，给药后48小时还会引起显著的肌酸尿症和肌酸血症。未导致睾丸坏死的镉剂量不会引起肌酸尿症或肌酸血症。精索静脉丛的手术结扎也会导致睾丸缺血性坏死，随后会出现显著的肌酸尿症和肌酸血症。然而，无论是切除睾丸后给予毒性剂量的镉、单纯切除睾丸还是假手术，均未引起显著的肌酸尿症或肌酸血症。镉给药会导致体重暂时下降，但其下降幅度小于食物限制所导致的体重下降。食物限制不会引起显著的肌酸尿症，但会引起显著的肌酸血症。这些数据表明，肌酸来源于受损的睾丸，尿肌酸的测量可能是检测因接触化学物质或血流机械性损伤导致的急性睾丸损伤的一种有用的非侵入性方法。
