Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
Federal University of Ouro Preto, Ouro Preto, Brazil.
J Bras Pneumol. 2014 Jul-Aug;40(4):429-42. doi: 10.1590/s1806-37132014000400012.
Malignant mesothelioma (MM) is a highly aggressive form of cancer, has a long latency period, and is resistant to chemotherapy. It is extremely fatal, with a mean survival of less than one year. The development of MM is strongly correlated with exposure to asbestos and with other factors, such as erionite and simian virus 40 [corrected]. Although various countries have banned the use of asbestos, MM has proven to be difficult to control and there appears to be a trend toward an increase in its incidence in the years to come. In Brazil, MM has not been widely studied from a genetic or biochemical standpoint. In addition, there have been few epidemiological studies of the disease, and the profile of its incidence has yet to be well established in the Brazilian population. The objective of this study was to review the literature regarding the processes of malignant transformation, as well as the respective mechanisms of tumorigenesis, in MM.
恶性间皮瘤（MM）是一种高度侵袭性的癌症，潜伏期长，对化疗有耐药性。它极其致命，平均生存时间不到一年。MM 的发展与石棉暴露以及其他因素密切相关，如毛沸石和猴病毒 40[已更正]。尽管各国已禁止使用石棉，但 MM 已被证明难以控制，而且未来几年其发病率似乎呈上升趋势。在巴西，MM 在遗传和生化方面尚未得到广泛研究。此外，对该疾病的流行病学研究很少，其在巴西人群中的发病情况尚未得到很好的确定。本研究旨在回顾关于 MM 恶性转化过程以及肿瘤发生的各自机制的文献。
