Fabbrocini G, De Vita V, Izzo R, Monfrecola G
Section of Dermatology, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy -
G Ital Dermatol Venereol. 2014 Oct;149(5):581-5.
The use of skin needling is believed to aid the transdermal delivery of drugs, even if it is mostly used for skin collagen induction. The aim of this paper was to use skin needling, combined with a local anesthetic EMLA (eutectic mixture of lidocaine and prilocaine), as a way to enhance transdermal drug penetration and optimize the analgesic effects of common local anesthesia.
We recruited 15 patients. For each patient of our study we defined a skin area of 3 cm2 from two forearms: on one side, we used skin needling first and immediately thereafter applied the EMLA in occlusion for 60 minutes; on the other one, we only applied EMLA in occlusion for 60 minutes. Then, pain was induced in each patient's forearm by introducing a 27 G needle into the skin 4 mm deep three times. Lastly, pain sensation measures were registered and a middle value was calculated.
When skin needling is used in conjunction with EMLA applied in occlusion for 60 minutes on skin forearms, the level of pain sensation registered was significantly reduced on a Visual Analogue Scale compared to the application of EMLA alone.
The use of skin needling can improve the transdermal delivery of an emulsion-like eutectic mixture of local anesthetics (EMLA) and can introduce the use of this method for delivering topical molecules in dermatology.
皮肤针刺疗法被认为有助于药物的透皮给药，即便其主要用于诱导皮肤胶原蛋白生成。本文旨在采用皮肤针刺疗法，联合局部麻醉药复方利多卡因乳膏（EMLA，利多卡因和丙胺卡因的共熔混合物），以增强药物透皮渗透，并优化常用局部麻醉的镇痛效果。
我们招募了15名患者。对于本研究中的每位患者，我们从双侧前臂划定了3平方厘米的皮肤区域：一侧先采用皮肤针刺疗法，随后立即敷用复方利多卡因乳膏并封闭60分钟；另一侧仅敷用复方利多卡因乳膏并封闭60分钟。然后，通过将一根27G的针头分三次刺入每位患者前臂皮肤4毫米深处来诱发疼痛。最后，记录疼痛感觉测量值并计算中位数。
在前臂皮肤上，当皮肤针刺疗法与敷用复方利多卡因乳膏并封闭60分钟联合使用时，与单独使用复方利多卡因乳膏相比，视觉模拟量表记录的疼痛感觉水平显著降低。
皮肤针刺疗法的应用可改善局部麻醉药乳状共熔混合物（复方利多卡因乳膏）的透皮给药，并可引入该方法用于皮肤科局部分子的递送。
