Kretz Florian T A, Limberger Il-Joo, Auffarth Gerd U
From the David J. Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
From the David J. Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
J Cataract Refract Surg. 2014 Nov;40(11):1879-84. doi: 10.1016/j.jcrs.2014.04.025. Epub 2014 Sep 10.
To compare the corneal endothelial coating of a new hyaluronic acid ophthalmic viscosurgical device (OVD) with dispersive properties with that of a standard hyaluronic acid OVD with cohesive properties.
David J. Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University of Heidelberg, Germany.
Experimental study.
The corneal endothelial cell coating of a new dispersive OVD (sodium hyaluronate 3% [Healon Endocoat]) and a standard cohesive hyaluronic acid OVD (sodium hyaluronate 1.4% [Healon GV]) as well as their combination using the soft-shell technique were evaluated. All OVDs were stained with fluorescein. Each of the 3 test groups comprised 10 porcine eyes. Cataract surgery was performed with identical phacoemulsification settings and time frames. Afterward, the cornea was trephined and a photograph taken of the endothelial side under blue light. The corneal coating with OVD was evaluated using planimetric image-analysis software.
The least endothelial coating was in the cohesive group (71%), while the dispersive group had statistically significantly higher adherence to the endothelium (87%) (P=.0009). The greatest endothelial coating was in the soft-shell technique group (93%); however, the difference between that group and the dispersive group was not statistically significant (P=.0962).
The new dispersive hyaluronic acid OVD with a low molecular weight showed a greater adherence to the endothelial surface than the standard cohesive hyaluronic acid OVD with a higher molecular weight.
No author has a financial or proprietary interest in any material or method mentioned.
比较一种具有分散特性的新型透明质酸眼科粘弹剂（OVD）与一种具有粘性特性的标准透明质酸OVD的角膜内皮覆盖情况。
德国海德堡大学眼科系大卫·J·苹果国际眼病理实验室。
实验研究。
评估一种新型分散性OVD（3%透明质酸钠[Healon Endocoat]）、一种标准粘性透明质酸OVD（1.4%透明质酸钠[Healon GV]）以及使用软壳技术将它们联合使用后的角膜内皮细胞覆盖情况。所有OVD均用荧光素染色。3个测试组每组包含10只猪眼。白内障手术在相同的超声乳化设置和时间范围内进行。之后，对角膜进行环钻，并在蓝光下拍摄内皮面的照片。使用平面图像分析软件评估OVD在角膜上的覆盖情况。
粘性组的内皮覆盖最少（71%），而分散组对内皮的粘附在统计学上显著更高（87%）（P = 0.0009）。内皮覆盖最多的是软壳技术组（93%）；然而，该组与分散组之间的差异无统计学意义（P = 0.0962）。
新型低分子量分散性透明质酸OVD比标准的高分子量粘性透明质酸OVD对内皮表面的粘附性更强。
没有作者对文中提及的任何材料或方法拥有财务或专利权益。
