Fortunato John E, Wagoner Ashley L, Harbinson Rachel L, D'Agostino Ralph B, Shaltout Hossam A, Diz Debra I
*Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, University of Colorado, Aurora †Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition ‡Hypertension and Vascular Research Center §Neuroscience Graduate Program, Wake Forest Graduate School of Arts & Sciences ||Department of Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC.
J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):39-43. doi: 10.1097/MPG.0000000000000305.
We hypothesized that orthostatic intolerance (OI) is associated with gastric dysrhythmias, nausea, and abdominal pain, which improves using fludrocortisone to treat OI.
Patients (n=16, girls) with OI completed questionnaires before and after fludrocortisone treatment (age 14.8 ± 2.8 years). Ten patients underwent electrogastrograms (EGGs) before fludrocortisone.
All EGGs showed gastric dysrhythmias. Fludrocortisone reduced mean scores as follows: nausea, 3.1 ± 0.8 to 2.1 ± 1.1 (P=0.016); dizziness, 3.0 ± 1.0 to 2.2 ± 1.1 (P=0.0371); abdominal pain, 2.8 ± 1.3 to 1.9 ± 1.4 (P=0.0063); flushing, 2.3 ± 1.2 to 1.5 ± 1.4 (P=0.0476); and missing school, 2.2 ± 1.5 to 1.2 ± 1.5 (P=0.0078).
Chronic nausea and abdominal pain accompany OI and improve with OI treatment.
我们推测体位性不耐受（OI）与胃节律紊乱、恶心和腹痛有关，使用氟氢可的松治疗OI可改善这些症状。
16例（均为女孩）患有OI的患者在接受氟氢可的松治疗前后完成问卷调查（年龄14.8±2.8岁）。10例患者在接受氟氢可的松治疗前进行了胃电图（EGG）检查。
所有EGG检查均显示胃节律紊乱。氟氢可的松使平均得分降低如下：恶心，从3.1±0.8降至2.1±1.1（P=0.016）；头晕，从3.0±1.0降至2.2±1.1（P=0.0371）；腹痛，从2.8±1.3降至1.9±1.4（P=0.0063）；脸红，从2.3±1.2降至1.5±1.4（P=0.0476）；缺课，从2.2±1.5降至1.2±1.5（P=0.0078）。
慢性恶心和腹痛与OI相伴，且随着OI的治疗而改善。
