从海洋软珊瑚艾氏肉芝软珊瑚中分离、结构鉴定及合成（SE）-2-甲基辛基3-（4-甲氧基苯基）丙烯酸酯。

Isolation, structural assignment and synthesis of (SE)-2-methyloctyl 3-(4-methoxyphenyl) propenoate from the marine soft coral Sarcophyton ehrenbergi.

作者信息

Bhujanga Rao Chitturi, Babu Dokuburra Chanti, Bharadwaj Tatipamula Vinay, Srikanth Dudem, Vardhan Kalivendi Shasi, Raju Tuniki Venugopal, Bunce Richard A, Venkateswarlu Yenamandra

机构信息

a Natural Products Chemistry Division , Indian Institute of Chemical Technology , Hyderabad 500 007 , India.

出版信息

Nat Prod Res. 2015;29(1):70-6. doi: 10.1080/14786419.2014.958742. Epub 2014 Sep 17.

DOI:10.1080/14786419.2014.958742

PMID:25229804

Abstract

A new metabolite 1 has been isolated from the marine soft coral Sarcophyton ehrenbergi along with two known diterpenoids 2 and 3 and cholesterol 4. The structure of 1 was determined by means of detailed spectroscopic analysis and unambiguously confirmed to have the S configuration by the synthesis of both enantiomers using 4-benzyl-2-oxazolidinone auxiliaries. (S)- and (R)-1, 3 and some of the synthetic intermediates were evaluated for cytotoxic activity against human lung cancer (A549), prostate cancer (DU145), cervical cancer (HeLa) and breast cancer (MCF-7) cell lines in an in vitro bioassay.

摘要

从海洋软珊瑚埃氏肉芝软珊瑚中分离出一种新的代谢产物1，同时还分离出两种已知的二萜类化合物2和3以及胆固醇4。通过详细的光谱分析确定了1的结构，并使用4-苄基-2-恶唑烷酮助剂合成了两种对映体，明确证实其具有S构型。在体外生物测定中，对（S）-1和（R）-1、3以及一些合成中间体进行了针对人肺癌（A549）、前列腺癌（DU145）、宫颈癌（HeLa）和乳腺癌（MCF-7）细胞系的细胞毒性活性评估。