State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China.
Adv Mater. 2014 Nov 19;26(43):7393-8. doi: 10.1002/adma.201403562. Epub 2014 Sep 19.
A strategy to prepare doxorubicin-loaded magnetic silk fibroin nanoparticles is presented. The nanoparticles serve as a nanometer-scale drug-delivery system in the chemotherapy of multidrug-resistant cancer under the guidance of a magnetic field. The magnetic tumor-targeting ability broadens the range of biomedical applications of silk fibroin, and the nanoparticle-assisted preparation strategy is useful for the advancement of other biomacromolecule-based materials.
本文提出了一种载阿霉素磁性丝素纳米粒子的制备策略。这些纳米粒子在磁场引导下作为一种纳米级药物输送系统，应用于多药耐药性肿瘤的化学治疗。磁性肿瘤靶向能力拓宽了丝素生物医学应用的范围，纳米粒子辅助的制备策略有助于推进其他基于生物大分子的材料的发展。
Zotero 插件