Shewale Jitesh B, Correa Arlene M, Baker Carla M, Villafane-Ferriol Nicole, Hofstetter Wayne L, Jordan Victoria S, Kehlet Henrik, Lewis Katie M, Mehran Reza J, Summers Barbara L, Schaub Diane, Wilks Sonia A, Swisher Stephen G
*Department of Thoracic and Cardiovascular Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX †Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX; and ‡Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Ann Surg. 2015 Jun;261(6):1114-23. doi: 10.1097/SLA.0000000000000971.
To evaluate the effects of a fast-track esophagectomy protocol (FTEP) on esophageal cancer patients' safety, length of hospital stay (LOS), and hospital charges.
FTEP involved transferring patients to the telemetry unit instead of the surgical intensive care unit (SICU) after esophagectomy.
We retrospectively reviewed 708 consecutive patients who underwent esophagectomy for primary esophageal cancer during the 4 years before (group A; 322 patients) or 4 years after (group B; 386 patients) the institution of an FTEP. Postoperative morbidity and mortality, LOS, and hospital charges were reviewed.
Compared with group A, group B had significantly shorter median LOS (12 days vs 8 days; P < 0.001); lower mean numbers of SICU days (4.5 days vs 1.2 days; P < 0.001) and telemetry days (12.7 days vs 9.7 days; P < 0.001); and lower rates of atrial arrhythmia (27% vs 19%; P = 0.013) and pulmonary complications (27% vs 20%; P = 0.016). Multivariable analysis revealed FTEP to be associated with shorter LOS (P < 0.001) even after adjustment for predictors like tumor histology and location. FTEP was also associated with a lower rate of pulmonary complications (odds ratio = 0.655; 95% confidence interval = 0.456, 0.942; P = 0.022). In addition, the median hospital charges associated with primary admission and readmission within 90 days for group B ($65,649) were lower than that for group A ($79,117; P < 0.001).
These findings suggest that an FTEP reduces patients' LOS, perioperative morbidity, and hospital charges.
评估快速通道食管癌切除方案(FTEP)对食管癌患者安全性、住院时间(LOS)及住院费用的影响。
FTEP包括食管癌切除术后将患者转至遥测监护病房而非外科重症监护病房(SICU)。
我们回顾性分析了在实施FTEP之前4年(A组;322例患者)或之后4年(B组;386例患者)连续接受原发性食管癌切除术的708例患者。对术后发病率、死亡率、LOS及住院费用进行了评估。
与A组相比,B组的中位LOS显著缩短(12天对8天;P<0.001);SICU天数的平均数更低(4.5天对1.2天;P<0.001),遥测监护天数也更低(12.7天对9.7天;P<0.001);房性心律失常发生率(27%对19%;P=0.013)和肺部并发症发生率(27%对20%;P=0.016)更低。多变量分析显示,即使在对肿瘤组织学和位置等预测因素进行校正后,FTEP仍与较短的LOS相关(P<0.001)。FTEP还与较低的肺部并发症发生率相关(比值比=0.655;95%置信区间=0.456,0.942;P=0.022)。此外,B组初次入院及90天内再次入院的中位住院费用(65,649美元)低于A组(79,117美元;P<0.001)。
这些研究结果表明,FTEP可缩短患者的LOS、降低围手术期发病率及住院费用。