一项多中心研究中青光眼治疗依从性的预测因素
Predictors of adherence to glaucoma treatment in a multisite study.
作者信息
Cook Paul F, Schmiege Sarah J, Mansberger Steven L, Kammer Jeffrey, Fitzgerald Timothy, Kahook Malik Y
机构信息
University of Colorado College of Nursing, University of Colorado, Campus Box C288-04, Aurora, CO, 80045, USA,
出版信息
Ann Behav Med. 2015 Feb;49(1):29-39. doi: 10.1007/s12160-014-9641-8.
BACKGROUND
Poor adherence hinders glaucoma treatment. Studies have identified demographic and clinical predictors of adherence but fewer psychological variables.
PURPOSE
We examined predictors from four health behavior theories and past research.
METHODS
In the baseline phase of a three-site adherence study, before any intervention, 201 participants used electronic Medication Event Monitoring System (MEMS) bottles to monitor eyedrop use for 2 months, and completed questionnaires including self-reported adherence.
RESULTS
MEMS showed 79% adherence and self-report 94% (0.5-1.5 missed weekly doses), but they correlated only r(s) = 0.31. Self-efficacy, motivation, dose frequency, and nonminority race/ethnicity predicted 35% of variance in MEMS. Cues to action, self-efficacy, and intention predicted 20% of variance in self-reported adherence.
CONCLUSIONS
Self-efficacy, motivation, intention, cues to action, dose frequency, and race/ethnicity each independently predicted adherence. Predictors from all theories were supported in bivariate analyses, but additional study is needed. Researchers and clinicians should consider psychological predictors of adherence. (ClinicalTrials.gov ID# NCT01409421.).
背景
依从性差会阻碍青光眼治疗。研究已确定了依从性的人口统计学和临床预测因素，但心理变量较少。
目的
我们研究了来自四种健康行为理论和以往研究的预测因素。
方法
在一项三中心依从性研究的基线阶段，在任何干预措施实施之前，201名参与者使用电子药物事件监测系统（MEMS）药瓶监测眼药水使用情况2个月，并完成包括自我报告依从性在内的问卷调查。
结果
MEMS显示依从率为79%，自我报告的依从率为94%（每周漏服剂量0.5 - 1.5次），但二者的相关性仅为r(s)=0.31。自我效能感、动机、给药频率以及非少数族裔种族/民族预测了MEMS中35%的方差。行动提示、自我效能感和意图预测了自我报告依从性中20%的方差。
结论
自我效能感、动机、意图、行动提示、给药频率以及种族/民族各自独立地预测了依从性。所有理论中的预测因素在双变量分析中均得到支持，但仍需进一步研究。研究人员和临床医生应考虑依从性的心理预测因素。（ClinicalTrials.gov标识符#NCT01409421。）
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