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T cell receptor beta gene has two downstream DNase I hypersensitive regions. Possible mechanisms of tissue- and stage-specific gene regulation.T细胞受体β基因有两个下游DNA酶I超敏区域。组织和阶段特异性基因调控的可能机制。
J Exp Med. 1989 Jun 1;169(6):2097-107. doi: 10.1084/jem.169.6.2097.
2
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Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNase I-hypersensitive in hemopoietic progenitor cells.免疫球蛋白重链和CD3δ链基因增强子在造血祖细胞中对DNA酶I敏感。
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Alpha beta T-cell development is not affected by inversion of TCR beta gene enhancer sequences: polar enhancement of gene expression regardless of enhancer orientation.αβ T细胞的发育不受TCRβ基因增强子序列倒置的影响：无论增强子方向如何，基因表达均呈极性增强。
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Direct and indirect mechanisms of repression participate in suppression of T-cell-specific gene expression in T x L-cell hybrids.直接和间接的抑制机制参与了T细胞与L细胞杂交体中T细胞特异性基因表达的抑制过程。
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4
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5
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Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins.小鼠T细胞受体β增强子的功能分析及其DNA结合蛋白的特性
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8
Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.tal-1癌蛋白与E47/E12螺旋-环-螺旋蛋白相关的增强子结合活性。
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T细胞受体β基因有两个下游DNA酶I超敏区域。组织和阶段特异性基因调控的可能机制。

T cell receptor beta gene has two downstream DNase I hypersensitive regions. Possible mechanisms of tissue- and stage-specific gene regulation.

作者信息

Hashimoto Y

机构信息

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104.

出版信息

J Exp Med. 1989 Jun 1;169(6):2097-107. doi: 10.1084/jem.169.6.2097.

DOI:10.1084/jem.169.6.2097
PMID:2525173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189349/
Abstract

Two DNase I-hypersensitive regions were identified downstream of the TCR gene constant region. One of these regions is located at the site of a putative enhancer element and was observed only in T cell lines and not in cell lines derived from other tissues. The other DNase-hypersensitive region was also detected only in T cell lines but only in those expressing TCR-beta RNA. Thus, the first region is probably tissue specific, while the second region is probably tissue and stage specific. The DNA sequence of the second DNase I-hypersensitive region revealed several stretches of nucleotides that are characteristic of consensus sequences for regulatory elements. These results, together with the observations in transgenic mice that indicate a requirement for two distinct regions for optimal TCR gene expression, suggest the presence of at least two regulatory regions downstream of the C-beta-2 region; one is an enhancer region and the other is a transcriptionally related regulatory region. The tissue/stage specificity of these DNase I-hypersensitive regions supports the notion that changes in chromatin structure control tissue-specific gene expression.

摘要

在TCR基因恒定区下游鉴定出两个DNase I超敏区域。其中一个区域位于一个假定增强子元件的位点，且仅在T细胞系中观察到，而在源自其他组织的细胞系中未观察到。另一个DNase超敏区域也仅在T细胞系中检测到，但仅在那些表达TCR-β RNA的细胞系中检测到。因此，第一个区域可能是组织特异性的，而第二个区域可能是组织和阶段特异性的。第二个DNase I超敏区域的DNA序列揭示了几段核苷酸序列，这些序列是调控元件共有序列的特征。这些结果，连同在转基因小鼠中的观察结果（表明最佳TCR基因表达需要两个不同区域），提示在C-β-2区域下游至少存在两个调控区域；一个是增强子区域，另一个是转录相关调控区域。这些DNase I超敏区域的组织/阶段特异性支持了染色质结构变化控制组织特异性基因表达这一观点。