抑郁症与阿尔茨海默病（AD）中的认知障碍：从抑郁症到AD的渐变。

Impaired cognition in depression and Alzheimer (AD): a gradient from depression to depression in AD.

作者信息

Araujo Narahyana Bom de, Moraes Helena Sales, Silveira Heitor, Arcoverde Cynthia, Vasques Paulo Eduardo, Barca Maria Lage, Knapskog Anne-Brita, Engedal Knut, Coutinho Evandro Silva Freire, Deslandes Andrea Camaz, Laks Jerson

机构信息

Laboratório de Neurociência do Exercício, Universidade Gama Filho, Rio de Janeiro, RJ, Brazil.

Centro Universitário, Instituto Brasileiro de Medicina de Reabilitação, Rio de Janeiro, RJ, Brazil.

出版信息

Arq Neuropsiquiatr. 2014 Sep;72(9):671-9. doi: 10.1590/0004-282x20140108.

DOI:10.1590/0004-282x20140108

PMID:25252230

Abstract

OBJECTIVE

To assess cognition in major depressed (MD), Alzheimer's disease (AD), and depression in AD elderly.

METHOD

Subjects were evaluated by Mini Mental, Rey Auditory Verbal Learning Test, Rey Complex Figure, Digit Span, Similarities, Trail Making A/B, Verbal Fluency and Stroop. One-way ANOVA and multivariate models were used to compare the performance of each group on neuropsychological tests.

RESULTS

We evaluated 212 subjects. Compared to MD, attention, working memory, processing speed and recall showed significantly better in controls. Controls showed significantly higher performance in all cognitive measures, except in attention compared to AD. Verbal fluency, memory, processing speed and abstract reasoning in MD was significantly higher compared to AD. AD was significantly better in general cognitive state than depression in AD. All other cognitive domains were similar.

CONCLUSION

A decreasing gradient in cognition appeared from the control to depression in AD, with MD and AD in an intermediate position.

摘要

目的

评估重度抑郁症（MD）、阿尔茨海默病（AD）以及AD老年患者中的抑郁症患者的认知情况。

方法

通过简易精神状态检查表、雷伊听觉词语学习测验、雷伊复杂图形测验、数字广度测验、相似性测验、连线测验A/B、语言流畅性测验和斯特鲁普测验对受试者进行评估。采用单因素方差分析和多变量模型比较各组在神经心理学测试中的表现。

结果

我们评估了212名受试者。与MD组相比，对照组在注意力、工作记忆、处理速度和回忆方面表现显著更好。与AD组相比，对照组在所有认知指标上表现显著更高，但注意力除外。与AD组相比，MD组的语言流畅性、记忆、处理速度和抽象推理能力显著更高。AD组在总体认知状态方面显著优于AD合并抑郁症组。所有其他认知领域相似。