Department of Ophthalmology, Dow University of Health Sciences and Civil Hospital, Karachi, Pakistan.
PLoS One. 2012;7(5):e37638. doi: 10.1371/journal.pone.0037638. Epub 2012 May 21.
To determine normal macular thickness and its variation by age and gender in healthy eyes using spectral-domain optical coherence tomography (SD-OCT).
In this cross-sectional analysis, two hundred and twenty eyes of 220 healthy subjects underwent raster scanning using Topcon SD-OCT system, at the Department of Ophthalmology, Dow University of Health Sciences and Civil Hospital Karachi, Pakistan. Macular thickness from all 9 regions of the ETDRS map was documented for each subject. Variations in macular thickness measurements by age and gender were determined.
The 220 subjects had a mean age of 45.3 years (16-80 years). Using the ETDRS map, foveal thickness for all subjects was measured to be 229±20.46 µm. Mean macular thickness for all subjects was 262.8±13.34 µm. Male gender was associated with greater foveal (p<0.0001) and mean macular (p<0.0001) thickness compared to females. There was no association of mean macular thickness (r(2) = 0.01; p>0.05) and foveal thickness (r(2) = 0.00004; p>0.05) with age.
We have provided normative data for macular thickness using Topcon SD-OCT system. Our results are comparable to some and vary from other reports using the similar OCT system. Our results suggest that male gender is associated with greater macular thickness, while macular thickness has no association with age in healthy eyes. This is the first normative data for macular thickness from Pakistan; benchmark for diagnosing and monitoring macular pathologies. The values obtained in this study may be useful for comparison with other populations, other SD-OCT systems and future imaging technologies.
使用谱域光相干断层扫描（SD-OCT）确定健康眼中黄斑厚度及其随年龄和性别的变化。
在这项横断面分析中，巴基斯坦达吾德大学健康科学系和卡拉奇民事医院眼科的 220 名 220 名健康受试者使用 Topcon SD-OCT 系统进行了光栅扫描。为每位受试者记录了 ETDRS 图谱的所有 9 个区域的黄斑厚度。确定了黄斑厚度测量值随年龄和性别的变化。
220 名受试者的平均年龄为 45.3 岁（16-80 岁）。使用 ETDRS 图谱，所有受试者的中心凹厚度均为 229±20.46 µm。所有受试者的平均黄斑厚度为 262.8±13.34 µm。与女性相比，男性的中心凹（p<0.0001）和平均黄斑（p<0.0001）厚度更大。平均黄斑厚度（r(2) = 0.01；p>0.05）和中心凹厚度（r(2) = 0.00004；p>0.05）与年龄均无关联。
我们使用 Topcon SD-OCT 系统提供了黄斑厚度的正常数据。我们的结果与使用类似 OCT 系统的一些报告相似，但与其他报告不同。我们的结果表明，男性与更大的黄斑厚度相关，而黄斑厚度与健康眼中的年龄无关。这是巴基斯坦首次提供黄斑厚度的正常数据；是诊断和监测黄斑病变的基准。本研究获得的值可能有助于与其他人群、其他 SD-OCT 系统和未来成像技术进行比较。
