The Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria.
Retina. 2011 Jan;31(1):41-7. doi: 10.1097/IAE.0b013e3181dde71e.
To assess reproducibility and compare raster scanning protocols of Cirrus high-definition optical coherence tomography (Carl Zeiss Meditec, Dublin, CA).
Five hundred and twenty-eight computed tomography scans were performed in 17 healthy subjects. Four sessions were performed at each visit including two 200 × 200 and two 512 × 128 macular cube scans per session. The examined eye, observer, and order of scanning protocols in-between each session were randomly chosen. Reproducibility was described with intraclass correlation coefficients, coefficients of variance, intervisit, interrater, intersession intra-, and intersubject standard deviations.
Intraclass correlation coefficients ranged from 80.4% to 97.8% and the coefficients of variance from 0.7% to 2.3% for retinal volume and retinal thickness measurements. Intersubject, intervisit, interrater, intersession, and intrasubject standard deviations ranged from 0 μm to 18.54 μm. Differences in retinal thickness between protocols were small (range 3.55 ± 1.95 μm to 0.81 ± 0.59 μm) but significant for the central (P < 0.0001), the outer superior (P = 0.0036), temporal (P = 0.0026), and nasal subfield (P < 0.0001). Average difference of retinal volume between protocols was 0.05 ± 0.04 mm (P = 0.0001).
Both raster scanning protocols of the Cirrus optical coherence tomography showed excellent reproducibility of retinal thickness and volume measures. Significant differences between protocols for retinal thickness in four macula thickness map subfields and for retinal volume were found.
评估 Cirrus 高清光学相干断层扫描（德国卡尔蔡司公司）的重现性并比较其光栅扫描协议。
对 17 名健康受试者进行了 528 次 CT 扫描。每次就诊时进行 4 次扫描，每次扫描包括两次 200×200 和两次 512×128 黄斑立方扫描。每次检查时，选择检查眼、观察者和扫描协议的顺序均为随机。采用组内相关系数、变异系数、随访间、观察者间、扫描间内和受试者间标准差来描述重复性。
视网膜体积和视网膜厚度测量的组内相关系数范围为 80.4%至 97.8%，变异系数范围为 0.7%至 2.3%。受试者间、随访间、观察者间、扫描间和受试者内标准差范围为 0μm 至 18.54μm。不同协议之间视网膜厚度的差异较小（范围为 3.55±1.95μm 至 0.81±0.59μm），但中央（P<0.0001）、外上方（P=0.0036）、颞侧（P=0.0026）和鼻侧子域（P<0.0001）的差异有统计学意义。不同协议之间视网膜体积的平均差异为 0.05±0.04mm（P=0.0001）。
Cirrus 光学相干断层扫描仪的两种光栅扫描协议均显示出视网膜厚度和体积测量的良好重现性。在四个黄斑厚度图子域和视网膜体积方面，发现了协议之间视网膜厚度的显著差异。
