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藿香正气口服液对乙酸诱导的感染后肠易激综合征大鼠肠黏膜机械屏障的保护作用。

Protective effect of huoxiang zhengqi oral liquid on intestinal mucosal mechanical barrier of rats with postinfectious irritable bowel syndrome induced by acetic Acid.

机构信息

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China ; New Drug Research and Development Center, Guangdong Institute of Traditional Chinese Medicine, Guangzhou 510520, China.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

出版信息

Evid Based Complement Alternat Med. 2014;2014:218383. doi: 10.1155/2014/218383. Epub 2014 Aug 28.

DOI:10.1155/2014/218383
PMID:25254052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4164314/
Abstract

In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of ZO-1 and occludin were examined to investigate protective effect mechanisms of HXZQ on intestinal mucosa barrier and then present experimental support for its use for prevention and cure of PI-IBS.

摘要

在这项研究中，使用乙酸诱导的 PI-IBS 大鼠模型研究了HXZQ 口服液在修复结肠上皮屏障和降低肠通透性中的作用。检查结肠组织的病理形态、上皮超微结构、血清中 DAO 活性以及 ZO-1 和闭合蛋白的蛋白表达，以研究 HXZQ 对肠黏膜屏障的保护作用机制，为其预防和治疗 PI-IBS 提供实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/374860fa9129/ECAM2014-218383.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/24fb1d1f9998/ECAM2014-218383.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/7ee8c9c46e57/ECAM2014-218383.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/62498bce4200/ECAM2014-218383.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/2b701aa64a4e/ECAM2014-218383.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/374860fa9129/ECAM2014-218383.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/24fb1d1f9998/ECAM2014-218383.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/7ee8c9c46e57/ECAM2014-218383.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/62498bce4200/ECAM2014-218383.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/2b701aa64a4e/ECAM2014-218383.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/4164314/374860fa9129/ECAM2014-218383.005.jpg

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