未接种疫苗的高危年轻成年人中的口腔人乳头瘤病毒（HPV）感染
Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults.
作者信息
D'Souza Gypsyamber, Kluz Nicole, Wentz Alicia, Youngfellow Renee M, Griffioen Anne, Stammer Emily, Guo Yingshi, Xiao Weihong, Gillison Maura L
机构信息
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Baltimore County Health Department, Baltimore, MD 21212, USA.
出版信息
Cancers (Basel). 2014 Aug 14;6(3):1691-704. doi: 10.3390/cancers6031691.
Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18-25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10-3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06-2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man.
口腔人乳头瘤病毒（HPV）感染是美国大多数口咽癌的病因，在高危年轻成年人中尚未得到充分研究。如果年龄在18 - 25岁的男性（n = 340）和女性（n = 270）拒绝接种HPV疫苗，就招募他们到巴尔的摩县性传播疾病诊所就诊。每位参与者进行30秒的口腔冲洗和漱口取样，检测37种HPV DNA类型，并进行危险因素调查。使用对数二项回归探索与现患感染相关的因素。男性的任何口腔HPV感染率（15.3%对7.8%，p = 0.004）和疫苗型口腔HPV（即HPV16/18/6/11：5.0%对1.1%，p = 0.007）感染率均高于女性。在多变量分析中，男性性别（调整后风险比[aPR] = 1.93，95%置信区间[CI] = 1.10 - 3.39）、近期口交性伴侣数量（p趋势 = 0.013）以及曾对女性进行口交（aPR = 1.73，95% CI = 1.06 - 2.82）与口腔HPV患病率增加相关。对女性进行口交可能比与男性进行口交带来更高的口腔HPV感染风险。
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