Mi Xue-Song, Yuan Ti-Fei, So Kwok-Fai
Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China ; Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
School of Psychology, Nanjing Normal University, Nanjing, People's Republic of China ; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
Clin Interv Aging. 2014 Sep 16;9:1563-71. doi: 10.2147/CIA.S67263. eCollection 2014.
Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.
正常眼压性青光眼（NTG）是一种进行性视神经病变，它类似于原发性开角型青光眼，但缺乏眼压升高或其他可导致视神经病变的缓解因素。本综述总结了动物模型和人类患者中NTG的病因、遗传学及潜在机制。我们还提出神经血管单元是NTG治疗的一个靶点。
