来自中国南海两种软珊瑚——曲纹肉芝软珊瑚和柔韧柳珊瑚的9,11-开环甾体和多羟基甾体。

9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis.

作者信息

Chen Wen-Ting, Liu Hai-Li, Yao Li-Gong, Guo Yue-Wei

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang High-Tech Park, Shanghai 201203, PR China.

出版信息

Steroids. 2014 Dec;92:56-61. doi: 10.1016/j.steroids.2014.08.027. Epub 2014 Sep 28.

DOI:10.1016/j.steroids.2014.08.027

PMID:25262997

Abstract

A new 9,11-secosteroid, 25(26)-dehydrosarcomilasterol (1), two new polyhydroxylated steroids, 7α-hydroxy-crassarosterol A (2) and 11-acetoxy-7α-hydroxy-crassarosterol A (3), together with three known related ones (4-6), were isolated from the South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis, respectively. The structures of the new steroids were elucidated on the basis of extensive spectroscopic analyses, comparison with the literature data and chemical correlation. Compound 2 exhibited a moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 33.05μM. Compounds 1-3 showed weak in vitro cytotoxicities against the tumor cell lines K562 and HL-60.

摘要

从中国南海软珊瑚环纹肉芝软珊瑚和柔指软珊瑚中分别分离得到一种新的9,11-开环甾体化合物25(26)-脱水肉芝甾醇(1)、两种新的多羟基甾体化合物7α-羟基厚叶甾醇A(2)和11-乙酰氧基-7α-羟基厚叶甾醇A(3)，以及三种已知的相关化合物(4-6)。通过广泛的光谱分析、与文献数据比较以及化学关联确定了新甾体化合物的结构。化合物2表现出中等程度的蛋白酪氨酸磷酸酶1B(PTP1B)抑制活性，IC50值为33.05μM。化合物1-3对肿瘤细胞系K562和HL-60显示出较弱的体外细胞毒性。