病例报告：委内瑞拉两名女性感染血小板无形体的分子证据。
Case report: Molecular evidence of Anaplasma platys infection in two women from Venezuela.
作者信息
Arraga-Alvarado Cruz M, Qurollo Barbara A, Parra Omaira C, Berrueta Maribel A, Hegarty Barbara C, Breitschwerdt Edward B
机构信息
Unidad de Investigaciones Clínicas, Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela; Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.
Unidad de Investigaciones Clínicas, Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela; Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina
出版信息
Am J Trop Med Hyg. 2014 Dec;91(6):1161-5. doi: 10.4269/ajtmh.14-0372. Epub 2014 Sep 29.
Abstract
This article presents two case reports of Anaplasma platys detection in two women from Venezuela. Both patients were exposed to Rhipicephalus sanguineus, the presumed tick vector, and experienced chronic, nonspecific clinical signs including headaches and muscle pains. Intra-platelet inclusion bodies resembling A. platys were observed in buffy coat smears and A. platys DNA was amplified and sequenced from whole blood; however, treatment with doxycycline did not alleviate their symptoms. These cases provide further support for A. platys as a zoonotic tick-borne pathogen, most likely of low pathogenicity; nonetheless, the cause of illness in humans by A. platys is yet to be confirmed.
摘要
本文介绍了在两名来自委内瑞拉的女性中检测到嗜吞噬细胞无形体的两例病例报告。两名患者均接触过推测为传播媒介的血红扇头蜱，并出现了包括头痛和肌肉疼痛在内的慢性非特异性临床症状。在血沉棕黄层涂片上观察到类似于嗜吞噬细胞无形体的血小板内包涵体，并且从全血中扩增并测序了嗜吞噬细胞无形体的DNA；然而，用强力霉素治疗并未缓解她们的症状。这些病例进一步支持嗜吞噬细胞无形体作为一种人畜共患的蜱传病原体，其致病性很可能较低；尽管如此，嗜吞噬细胞无形体导致人类疾病的原因尚未得到证实。
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