Weizman Adam V, Huang Brian, Targan Stephan, Dubinsky Marla, Fleshner Phillip, Kaur Manreet, Ippoliti Andrew, Panikkath Deepa, Vasiliauskas Eric, Shih David, McGovern Dermot P B, Melmed Gil Y
J Cutan Med Surg. 2014 Oct;18(5):361.
Pyoderma gangrenosum (PG) is a severe extraintestinal manifestation of inflammatory bowel disease (IBD).
To better characterize PG features and management among an IBD cohort.
Subjects with PG were identified using a large database at a tertiary center. Patient demographics and clinical characteristics were summarized using descriptive statistics.
Eighty patients with an episode(s) of PG were identified, yielding an overall prevalence of 1.9%. Overall, 93% of patients with PG had some degree of colonic inflammation. Thirty-one (39%) patients required hospitalization for PG. Underlying bowel disease was active at the time of PG episode(s) in 52 (65%) patients. The PG location was variable, with the lower extremity being the most common. Most patients (71.3%) required multiple therapies to achieve PG healing.
We describe one of the largest case series of PG among patients with IBD. The variety of treatment strategies used highlights the lack of clear guidelines in managing this complex group of patients.
坏疽性脓皮病（PG）是炎症性肠病（IBD）的一种严重肠外表现。
更好地描述IBD队列中PG的特征及管理情况。
利用一家三级中心的大型数据库识别出患有PG的受试者。使用描述性统计方法总结患者的人口统计学和临床特征。
识别出80例有PG发作的患者，总体患病率为1.9%。总体而言，93%的PG患者有一定程度的结肠炎症。31例（39%）患者因PG需要住院治疗。52例（65%）患者在PG发作时潜在的肠道疾病处于活动期。PG的发病部位各不相同，下肢最为常见。大多数患者（71.3%）需要多种治疗才能实现PG愈合。
我们描述了IBD患者中最大的PG病例系列之一。所采用的各种治疗策略凸显了在管理这一复杂患者群体方面缺乏明确的指南。
