Itoyama Y, Kira J, Fujii N, Goto I, Yamamoto N
Department of Neurology, Kyushu University, Fukuoka, Japan.
Ann Neurol. 1989 Aug;26(2):257-62. doi: 10.1002/ana.410260212.
Using two-color flow cytometric analysis, we studied peripheral blood lymphocyte subsets in 15 patients with human T-cell lymphotropic virus type I-associated myelopathy. The percentage of CD4+ 4B4+ cells (helper inducer T cell) was significantly increased in the patients with the myelopathy, compared with 16 healthy control subjects who were seronegative for human T-cell lymphotropic virus type I. However, there was no difference in the percentage of CD4+ 2H4+ cells (suppressor inducer T cell) between the two groups. The ratio of CD4+ 4B4+ cells to CD4+ cells and CD4+ 4B4+ to CD4+ 2H4+ cells was also elevated in these patients. The percentage of CD4+ DR+ cells and CD8+ DR+ cells, both of which are phenotypically activated T cells, and the ratio of CD4+ DR+ cells to CD4+ cells and of CD8+ DR+ cells to CD8+ cells are also increased in the patients, compared with the control subjects. The percentage of CD4+ 4B4+ cells showed positive correlations with values of spontaneous proliferation of peripheral blood lymphocytes and serum IgG level in patients with the myelopathy.
我们采用双色流式细胞术分析了15例成人T细胞白血病/淋巴瘤病毒I型相关脊髓病患者的外周血淋巴细胞亚群。与16例成人T细胞白血病/淋巴瘤病毒I型血清学阴性的健康对照者相比，脊髓病患者中CD4+ 4B4+细胞（辅助诱导性T细胞）的百分比显著升高。然而，两组间CD4+ 2H4+细胞（抑制诱导性T细胞）的百分比无差异。这些患者中CD4+ 4B4+细胞与CD4+细胞的比值以及CD4+ 4B4+与CD4+ 2H4+细胞的比值也升高。与对照者相比，患者中表型活化T细胞CD4+ DR+细胞和CD8+ DR+细胞的百分比以及CD4+ DR+细胞与CD4+细胞的比值和CD8+ DR+细胞与CD8+细胞的比值也增加。脊髓病患者中CD4+ 4B4+细胞的百分比与外周血淋巴细胞自发增殖值和血清IgG水平呈正相关。
