IEEE Trans Med Imaging. 2014 Oct;33(10):1954-9. doi: 10.1109/TMI.2014.2327515.
While magnetic particle imaging (MPI) constitutes a novel biomedical imaging technique for tracking superparamagnetic nanoparticles in vivo, unlike magnetic resonance imaging (MRI), it cannot provide anatomical background information. Until now these two modalities have been performed in separate scanners and image co-registration has been hampered by the need to reposition the sample in both systems as similarly as possible. This paper presents a bimodal MPI-MRI-tomograph that combines both modalities in a single system.MPI and MRI images can thus be acquired without moving the sample or replacing any parts in the setup. The images acquired with the presented setup show excellent agreement between the localization of the nanoparticles in MPI and the MRI background data. A combination of two highly complementary imaging modalities has been achieved.
虽然磁粒子成像 (MPI) 是一种用于在体追踪超顺磁纳米粒子的新型生物医学成像技术，但与磁共振成像 (MRI) 不同，它无法提供解剖背景信息。到目前为止，这两种模式都是在单独的扫描仪中进行的，由于需要尽可能将样品重新定位到两个系统中，因此图像配准受到阻碍。本文提出了一种双模 MPI-MRI 断层扫描仪，它将两种模式组合在一个系统中。因此，无需移动样品或更换设置中的任何部件即可获取 MPI 和 MRI 图像。所获取的图像显示，MPI 中纳米粒子的定位与 MRI 背景数据之间具有极好的一致性。已经实现了两种高度互补的成像模式的组合。
