Ferguson R Matthew, Khandhar Amit P, Kemp Scott J, Arami Hamed, Saritas Emine U, Croft Laura R, Konkle Justin, Goodwill Patrick W, Halkola Aleksi, Rahmer Jurgen, Borgert Jorn, Conolly Steven M, Krishnan Kannan M
IEEE Trans Med Imaging. 2015 May;34(5):1077-84. doi: 10.1109/TMI.2014.2375065. Epub 2014 Nov 25.
Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2(∗) -weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3 × greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.
磁粒子成像（MPI）在医学成像领域展现出了前景，尤其是在慢性肾病患者的血管造影方面。作为首个真正依赖纳米级材料特性的生物医学成像技术，MPI需要高度优化的磁性纳米粒子示踪剂来生成高质量图像。到目前为止，研究人员一直依赖为MRI T2（∗）加权成像优化的示踪剂，而这些示踪剂对MPI来说并非最优。在此，我们描述了针对MPI独特物理特性定制的新型示踪剂，它们通过有机相工艺合成并进行了功能化处理，以确保生物相容性和足够的体内循环时间。在体模的MPI图像中，定制示踪剂的信噪比高达现有商业示踪剂的3倍，且空间分辨率更高。
