Institute for Biological and Medical Imaging (IBMI), Helmholtz Center Munich, Ingolstädter Landstraβe 1, 85764 Neuherberg, Germany ; Faculty of Medicine, Technical University of Munich, Ismaninger Straβe 22, 81675 Munich, Germany.
Photoacoustics. 2013 Nov 12;1(3-4):68-73. doi: 10.1016/j.pacs.2013.10.002. eCollection 2013 Dec.
Optoacoustic imaging provides a unique combination of high optical contrast and excellent spatial resolution, making it ideal for simultaneous imaging of tissue anatomy as well as functional and molecular contrast in deep optically opaque tissues. We report on development of a portable clinical system for three-dimensional optoacoustic visualization of deep human tissues at video rate. Studies in human volunteers have demonstrated powerful performance in delivering high resolution volumetric multispectral optoacoustic tomography (vMSOT) images of tissue morphology and function, such as blood oxygenation parameters, in real time. Whilst most imaging modalities currently in clinical use are not able to deliver volumetric data with comparable time resolution, the presented imaging approach holds promise to attain new diagnostic and treatment monitoring value for multiple indications, such as cardiovascular and peripheral vascular disease, disorders related to the lymphatic system, breast lesions, arthritis and inflammation.
光声成像是一种集高光学对比度和优异空间分辨率于一体的技术，非常适合对深度不透明组织中的组织解剖结构以及功能和分子对比度进行同时成像。我们报告了一种用于在视频速率下对深度人体组织进行三维光声可视化的便携式临床系统的开发。在人体志愿者中的研究表明，该系统在实时提供组织形态和功能的高分辨率体积多光谱光声断层扫描（vMSOT）图像方面具有强大的性能，例如血氧参数。虽然目前临床使用的大多数成像方式都无法以可比的时间分辨率提供体积数据，但所提出的成像方法有望为多种适应症（如心血管和外周血管疾病、与淋巴系统相关的疾病、乳房病变、关节炎和炎症）提供新的诊断和治疗监测价值。
