Deán-Ben X Luís, Razansky Daniel
Opt Express. 2013 Nov 18;21(23):28062-71. doi: 10.1364/OE.21.028062.
We report on a novel hand-held imaging probe for real-time optoacoustic visualization of deep tissues in three dimensions. The system incorporates an annular two-dimensional array of ultrasonic sensors densely distributed on a spherical surface. Simultaneous recording and processing of time-resolved data from all the channels enables acquisition of entire volumetric data sets for each illumination laser pulse. The proposed solution utilizes a transparent membrane in order to allow efficient coupling of optoacoustically generated waves to the ultrasonic detectors while avoiding direct contact of the imaged object with the coupling medium. The hand-held approach further allows convenient handling of both pre-clinical experiments as well as clinical measurements in human subjects. Here we demonstrate an imaging speed of 10 volumetric frames per second with spatial resolution down to 200 micrometers in the imaged region while also achieving imaging depth of more than 1.5 cm in living tissues without signal averaging.
我们报道了一种新型手持式成像探头，用于对深部组织进行三维实时光声可视化。该系统包含一个环形二维超声传感器阵列，密集分布在球面上。对所有通道的时间分辨数据进行同步记录和处理，能够为每个照明激光脉冲采集完整的体积数据集。所提出的解决方案采用了透明膜，以便使光声产生的波有效地耦合到超声探测器，同时避免成像对象与耦合介质直接接触。手持式方法还便于进行临床前实验以及人体临床测量。在此，我们展示了每秒10个体积帧的成像速度，成像区域的空间分辨率低至200微米，同时在活体组织中无需信号平均即可实现超过1.5厘米的成像深度。
