Boone Charles
Banting and Best Department of Medical Research, Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada M5S 3E1.
Genetics. 2014 Oct;198(2):435-7. doi: 10.1534/genetics.114.169128.
THE Genetics Society of America's Edward Novitski Prize recognizes an extraordinary level of creativity and intellectual ingenuity in the solution of significant problems in genetics research. The 2014 recipient, Charles Boone, has risen to the top of the emergent discipline of postgenome systems biology by focusing on the global mapping of genetic interaction networks. Boone invented the synthetic genetic array (SGA) technology, which provides an automated method to cross thousands of strains carrying precise mutations and map large-scale yeast genetic interactions. These network maps offer researchers a functional wiring diagram of the cell, which clusters genes into specific pathways and reveals functional connections.
美国遗传学会的爱德华·诺维茨基奖旨在表彰在遗传学研究中解决重大问题时展现出的非凡创造力和智慧。2014年的获奖者查尔斯·布恩通过专注于遗传相互作用网络的全球图谱绘制，在新兴的后基因组系统生物学领域脱颖而出。布恩发明了合成遗传阵列（SGA）技术，该技术提供了一种自动方法，用于对携带精确突变的数千个菌株进行杂交，并绘制大规模酵母遗传相互作用图谱。这些网络图为研究人员提供了细胞的功能线路图，将基因聚类到特定途径中，并揭示功能联系。
