对十字仙掌藻甲醇提取物和乙醇提取物的抗菌、抗真菌及调节活性的评估。
Evaluation of antibacterial, antifungal and modulatory activity of methanol and ethanol extracts of Padina sanctae-crucis.
作者信息
Nogueira Lavouisier F B, Morais Edson C, Brito Maria A D, Santos Beatriz S, Vale Doanny L, Lucena Bruno F F, Figueredo Fernando G, Guedes Glaucia M M, Tintino Saulo R, Souza Celestina E S, Nogueira Raquel B S S, Matias Edinardo F F, Morais-Braga Maria Fb, Cunha Emídio V L, Lima Micheline A, Coutinho Henrique D M
机构信息
Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
Departamento de Química Biológica, Universidade Regional do Cariri - URCA, Crato - CE, Brasil.
出版信息
Afr Health Sci. 2014 Jun;14(2):372-6. doi: 10.4314/ahs.v14i2.12.
BACKGROUND
Multi-resistantmicroorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida tropicalis e Candida krusei are the main causes of microbial infections. Padina sanctae-crucis is a seaweed often used to check the contamination of ecosystems by materials such as heavy metals, but studies of the antimicrobial activity of the same seaweed were not found.
METHODS
The tests for the minimum inhibitory concentration and modulation of microbial resistance, with the use of ethanolic and methanolic extracts of Padina Sanctae-cruces combined with drugs of the class of aminoglycosides and antifungal were used to evaluate the activity against the cited microorganisms.
RESULTS
Was observed a modulation of antibiotic activity between the natural products and the E. coli and S. aureus strains, indicating a synergism and antagonism respectively.
CONCLUSIONS
The results showed a moderate modulatory effect against some microorganisms studied.
背景
多重耐药微生物，如大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌、热带念珠菌和克柔念珠菌，是微生物感染的主要原因。圣十字蕨藻是一种常用于检测重金属等物质对生态系统污染的海藻，但未发现对该海藻抗菌活性的研究。
方法
使用圣十字蕨藻的乙醇提取物和甲醇提取物与氨基糖苷类药物和抗真菌药物联合，进行最低抑菌浓度和微生物耐药性调节测试，以评估对上述微生物的活性。
结果
观察到天然产物与大肠杆菌和金黄色葡萄球菌菌株之间抗生素活性的调节，分别表明协同作用和拮抗作用。
结论
结果显示对某些研究的微生物有适度的调节作用。
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