从埃及植物黄花刺蕊草中提取的新型倍半萜α-亚甲基内酯。

New sesquiterpene alpha-methylene lactones from the Egyptian plant Jasonia candicans.

作者信息

Ahmed A A, Mahmoud A A, Williams H J, Scott A I, Reibenspies J H, Mabry T J

机构信息

Department of Chemistry, Faculty of Science, El-Minia University, Egypt.

出版信息

J Nat Prod. 1993 Aug;56(8):1276-80. doi: 10.1021/np50098a011.

DOI:10.1021/np50098a011

PMID:8229012

Abstract

Extracts of the plant Jasonia candicans possess antimicrobial activity. ET2O/MeOH extracts were subjected to liquid chromatography, and several sesquiterpenes were isolated and identified including the known compounds confertin [1], 4,11(13)-eudesmadien-12-oic acid [2], and 11-eudesmen-4-ol [3]. Two new diol alpha-methylene lactone antimicrobial agents were identified from nmr and mass spectral data and X-ray crystallography as (4 alpha, 5 alpha, 8 beta, 10 beta)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide [4] and (4 alpha, 5 alpha, 8 beta, 10 alpha)-4,10-dihydroxyl-1,11 (13)-guaidien-12,8-olide[5], which differ in stereochemistry at the C-10 tertiary alcohol center.

摘要

植物白苞筋骨草的提取物具有抗菌活性。将二氯甲烷/甲醇提取物进行液相色谱分析，分离并鉴定出了几种倍半萜，包括已知化合物 confertin [1]、4,11(13)-桉叶二烯-12-酸 [2] 和 11-桉叶-4-醇 [3]。通过核磁共振、质谱数据和 X 射线晶体学鉴定出两种新的二醇α-亚甲基内酯抗菌剂，分别为(4α, 5α, 8β, 10β)-4,10-二羟基-1,11(13)-愈创木二烯-12,8-内酯 [4] 和(4α, 5α, 8β, 10α)-4,10-二羟基-1,11(13)-愈创木二烯-12,8-内酯[5]，它们在 C-10 叔醇中心的立体化学不同。