Rhee Kwang-Ho, Park Jin-Sik, Cho Myung-Je
Department of Microbiology, Gyeongsang National University College of Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju, Korea.
Yonsei Med J. 2014 Nov;55(6):1453-66. doi: 10.3349/ymj.2014.55.6.1453.
Helicobacter pylori (H. pylori) undergoes decades long colonization of the gastric mucosa of half the population in the world to produce acute and chronic gastritis at the beginning of infection, progressing to more severe disorders, including peptic ulcer disease and gastric cancer. Prolonged carriage of H. pylori is the most crucial factor for the pathogenesis of gastric maladies. Bacterial persistence in the gastric mucosa depends on bacterial factors as well as host factors. Herein, the host and bacterial components responsible for the incipient stages of H. pylori infection are reviewed and discussed. Bacterial adhesion and adaptation is presented to explain the persistence of H. pylori colonization in the gastric mucosa, in which bacterial evasion of host defense systems and genomic diversity are included.
幽门螺杆菌（H. pylori）在世界上一半人口的胃黏膜中进行长达数十年的定植，在感染初期会引发急性和慢性胃炎，并发展为更严重的疾病，包括消化性溃疡病和胃癌。幽门螺杆菌的长期携带是胃部疾病发病机制的最关键因素。细菌在胃黏膜中的持续存在取决于细菌因素以及宿主因素。本文对幽门螺杆菌感染初期的宿主和细菌成分进行了综述和讨论。阐述了细菌的黏附与适应，以解释幽门螺杆菌在胃黏膜中定植的持续性，其中包括细菌对宿主防御系统的逃避和基因组多样性。
