附着于金表面的pH敏感细胞穿透肽的可逆激活。
Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces.
作者信息
Baio Joe E, Schach Denise, Fuchs Adrian V, Schmüser Lars, Billecke Nils, Bubeck Christoph, Landfester Katharina, Bonn Mischa, Bruns Michael, Weiss Clemens K, Weidner Tobias
机构信息
Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
Karlsruhe Institute of Technology, Institute for Applied Materials and Karlsruhe Nano Micro Facility, 76344 Eggenstein-Leopoldshafen, Germany.
出版信息
Chem Commun (Camb). 2015;51(2):273-275. doi: 10.1039/c4cc07278b.
Abstract
pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.
摘要
pH敏感的病毒融合蛋白模拟物被广泛吹捧为一种有前景的途径，可实现治疗性化合物跨脂质膜的位点特异性递送。在此，我们证明，一种设计用于实现可逆的、pH驱动的螺旋-线圈转变机制的融合蛋白模拟物，在与表面共价结合时仍保留其功能。
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