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附着于金表面的pH敏感细胞穿透肽的可逆激活。

Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces.

作者信息

Baio Joe E, Schach Denise, Fuchs Adrian V, Schmüser Lars, Billecke Nils, Bubeck Christoph, Landfester Katharina, Bonn Mischa, Bruns Michael, Weiss Clemens K, Weidner Tobias

机构信息

Max Planck Institute for Polymer Research, 55270 Mainz, Germany.

Karlsruhe Institute of Technology, Institute for Applied Materials and Karlsruhe Nano Micro Facility, 76344 Eggenstein-Leopoldshafen, Germany.

出版信息

Chem Commun (Camb). 2015;51(2):273-275. doi: 10.1039/c4cc07278b.

DOI:10.1039/c4cc07278b
PMID:25329926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4608256/
Abstract

pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.

摘要

pH敏感的病毒融合蛋白模拟物被广泛吹捧为一种有前景的途径，可实现治疗性化合物跨脂质膜的位点特异性递送。在此，我们证明，一种设计用于实现可逆的、pH驱动的螺旋-线圈转变机制的融合蛋白模拟物，在与表面共价结合时仍保留其功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d7/4608256/c2ad868dedb7/nihms-727780-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d7/4608256/8cfde5704239/nihms-727780-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d7/4608256/952807b11acd/nihms-727780-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d7/4608256/c2ad868dedb7/nihms-727780-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d7/4608256/8cfde5704239/nihms-727780-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d7/4608256/952807b11acd/nihms-727780-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d7/4608256/c2ad868dedb7/nihms-727780-f0004.jpg

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Mimicking cellular transport mechanism in stem cells through endosomal escape of new peptide-coated quantum dots.通过新肽涂层量子点的内体逃逸模拟干细胞中的细胞运输机制。
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构象约束的功能肽单层用于控制展示生物活性糖配体。
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Nanocapsules with specific targeting and release properties using miniemulsion polymerization.使用细乳液聚合制备具有特定靶向和释放性能的纳米胶囊。
Expert Opin Drug Deliv. 2013 May;10(5):593-609. doi: 10.1517/17425247.2013.772976. Epub 2013 Feb 22.
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Asymmetric catalysis at the mesoscale: gold nanoclusters embedded in chiral self-assembled monolayer as heterogeneous catalyst for asymmetric reactions.介观尺度的不对称催化：手性自组装单层中嵌入的金纳米簇作为不对称反应的多相催化剂。
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