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Oligonucleotide delivery by cell-penetrating "striped" nanoparticles.

作者信息

Jewell Christopher M, Jung Jin-Mi, Atukorale Prabhani U, Carney Randy P, Stellacci Francesco, Irvine Darrell J

机构信息

Depts. of Materials Science and Engineering and Biological Engineering, Koch Institute for Integrative Cancer Research, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA).

Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland).

出版信息

Angew Chem Int Ed Engl. 2011 Dec 16;50(51):12312-12315. doi: 10.1002/anie.201104514. Epub 2011 Oct 26.

DOI:10.1002/anie.201104514
PMID:22028047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3786135/
Abstract
摘要

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Duplex end breathing determines serum stability and intracellular potency of siRNA-Au NPs.双层末端呼吸决定了 siRNA-Au NPs 的血清稳定性和细胞内效力。
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Direct investigation of intracellular presence of gold nanoparticles via photothermal heterodyne imaging.通过光热外差成像直接探测金纳米粒子的细胞内存在。
ACS Nano. 2011 Apr 26;5(4):2587-92. doi: 10.1021/nn1023285. Epub 2011 Mar 18.
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Modulation of biological processes in the nucleus by delivery of DNA oligonucleotides conjugated with gold nanoparticles.通过与金纳米粒子结合的 DNA 寡核苷酸的递送来调节细胞核中的生物过程。
Biomaterials. 2011 Apr;32(10):2593-604. doi: 10.1016/j.biomaterials.2010.11.074. Epub 2011 Jan 19.
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Gold nanoparticle platforms as drug and biomacromolecule delivery systems.金纳米颗粒平台作为药物和生物大分子的输送系统。
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Gold nanoparticles for biology and medicine.金纳米颗粒在生物学和医学中的应用。
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The effect of nanometre-scale structure on interfacial energy.纳米尺度结构对界面能的影响。
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Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity.纳米医学中的金纳米颗粒：制备、成像、诊断、治疗及毒性
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