Steinberg Johannes, Katz Toam, Mousli Aiham, Frings Andreas, Casagrande Maria K, Druchkiv Vasyl, Richard Gisbert, Linke Stephan J
Department of Ophthalmology, UKE-University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany ; Care-Vision Germany, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Department of Ophthalmology, UKE-University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
J Ophthalmol. 2014;2014:579190. doi: 10.1155/2014/579190. Epub 2014 Sep 22.
Purpose. To evaluate the effect of corneal crosslinking in progressive keratoconus by applying in vivo corneal visualization Scheimpflug technology. Design. Longitudinal retrospective study. Subjects and Controls. Seventeen eyes of patients treated with corneal crosslinking for progressive keratoconus. Methods. Corneal visualization Scheimpflug technology analyses (research software version 6.07r08) of subjects with progressive keratoconus before and 3 months after corneal crosslinking (CXL) were reviewed retrospectively. t-test (for normal distribution) and Wilcoxon matched-pairs test (if not normally distributed) were used to test for statistically significant differences between pre- and post-CXL analyses. Results. We demonstrated statistically significant differences for the intraocular pressure (median: +3 mmHg, P = 0.004), the central corneal pachymetry (pachy; mean: -35 µm, P < 0.001), the timespan between the air impulse release and the first applanation of the cornea (A1time; median: +0.12 ms, P < 0.05), and the timespan between the air impulse release and the second applanation of the cornea (A2time; median: -37 ms, P < 0.05). Conclusions. With the A1time and the A2time, we identified two parameters that demonstrated a statistically significant improvement of the biomechanical properties of the cornea after CXL. Despite the known initial decrease of the pachymetry after CXL, none of the analyzed parameters indicated a progression of the keratoconus.
目的。通过应用体内角膜可视化Scheimpflug技术评估角膜交联术对进展性圆锥角膜的疗效。设计。纵向回顾性研究。研究对象与对照。17例接受角膜交联术治疗进展性圆锥角膜患者的17只眼。方法。回顾性分析进展性圆锥角膜患者在角膜交联术（CXL）前及术后3个月的角膜可视化Scheimpflug技术分析结果（研究软件版本6.07r08）。采用t检验（用于正态分布）和Wilcoxon配对检验（若不呈正态分布）来检验CXL术前和术后分析之间的统计学显著差异。结果。我们发现眼内压（中位数：+3 mmHg，P = 0.004）、中央角膜厚度测量值（厚度；平均值：-35 µm，P < 0.001）、空气脉冲释放至角膜首次压平的时间间隔（A1时间；中位数：+0.12 ms，P < 0.05）以及空气脉冲释放至角膜第二次压平的时间间隔（A2时间；中位数：-37 ms，P < 0.05）存在统计学显著差异。结论。通过A1时间和A2时间，我们确定了两个参数，它们显示CXL术后角膜生物力学性能有统计学显著改善。尽管已知CXL术后角膜厚度最初会降低，但所分析的参数均未表明圆锥角膜有进展。
