Dziedzic Katarzyna, Zalewski Mateusz, Gadek Artur, Drukała Justyna
Przegl Lek. 2014;71(6):334-9.
Cartilage reconstruction is a crucial issue for tissue engineering because of high damage frequency in connection with low regenerative capacity. Microfractures and shaving are the oldest and most commonly used practices. The newest techniques are: Autologous Chondrocyte Implantation, Matrix Associated Chondrocytes Implantation and their derivatives. Dedifferentiation of chondrocytes due to low proliferation rate and phenotype loss makes isolation and in vitro culture of normal human chondrocytes very complex. Therefore, obtaining mesenchymal stem cells from various sources and differentiating them into chondrocytes is another interesting approach.
由于软骨损伤频率高且再生能力低，软骨重建是组织工程中的一个关键问题。微骨折和刨削是最古老且最常用的方法。最新技术包括：自体软骨细胞植入、基质相关软骨细胞植入及其衍生技术。由于增殖率低和表型丧失导致软骨细胞去分化，使得正常人软骨细胞的分离和体外培养非常复杂。因此，从各种来源获取间充质干细胞并将其分化为软骨细胞是另一种有趣的方法。
