Wang Lu, Xing Jiannan, Chen Fangfang, Yan Ruixue, Ge Lin, Qin Qianqian, Wang Liyan, Ding Zhengwei, Guo Wei, Wang Ning
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Beijing Human Resources and Social Security Bureau, Beijing, China.
PLoS One. 2014 Oct 30;9(10):e110861. doi: 10.1371/journal.pone.0110861. eCollection 2014.
The burden of Hepatitis C virus (HCV) has become more and more considerable in China. A macroscopic spatial analysis of HCV infection that can provide scientific information for further intervention and disease control is lacking.
All geo-referenced HCV cases that had been recorded by the China Information System for Disease Control and Prevention (CISDCP) during 2005-2011 were included in the study. In order to learn about the changes of demographic characteristics and geographic distribution, trend test and spatial analysis were conducted to reflect the changing pattern of HCV infection.
Over 770,000 identified HCV infection cases had specific geographic information during the study period (2005-2011). Ratios of gender (Male/Female, Z-value = -18.53, P<0.001), age group (≤30 years old/≥31 years old, Z-value = -51.03, P<0.001) and diagnosis type (Clinical diagnosis/Laboratory diagnosis, Z-value = -130.47, P<0.001) declined. HCV infection was not distributed randomly. Provinces Henan, Guangdong, Guangxi, Xinjiang, and Jilin reported more than 40,000 HCV infections during 2005 to 2011, accounting for 43.91% of all cases. The strength of cluster of disease was increasing in China during the study period. Overall, 11 provinces had once been detected as hotspots during 7 years, most of which were located in the central or border parts of China. Tibet, Qinghai, Jiangxi were the regions that had coldspots.
The number of clustering of HCV infection among older adults increased in recent years. Specific interventions and prevention programs targeting at main HCV epidemic areas are urgently in need in mainland China.
丙型肝炎病毒（HCV）在中国造成的负担日益加重。目前缺乏对HCV感染的宏观空间分析，而这种分析可为进一步干预和疾病控制提供科学依据。
本研究纳入了中国疾病预防控制信息系统（CISDCP）在2005年至2011年期间记录的所有带有地理信息的HCV病例。为了解人口统计学特征和地理分布的变化情况，进行了趋势检验和空间分析以反映HCV感染的变化模式。
在研究期间（2005 - 2011年），超过77万例确诊的HCV感染病例具有特定地理信息。性别比例（男/女，Z值 = -18.53，P < 0.001）、年龄组（≤30岁/≥31岁，Z值 = -51.03，P < 0.001）和诊断类型（临床诊断/实验室诊断，Z值 = -130.47，P < 0.001）的比例均有所下降。HCV感染并非随机分布。2005年至2011年期间，河南、广东、广西、新疆和吉林五省报告的HCV感染病例超过4万例，占所有病例的43.91%。在研究期间，中国疾病聚集的强度在增加。总体而言，7年间有11个省份曾被检测为热点地区，其中大部分位于中国中部或边境地区。西藏、青海、江西为冷点地区。
近年来，老年人中HCV感染聚集的数量有所增加。中国大陆迫切需要针对主要HCV流行地区制定具体的干预措施和预防方案。
