Staal S P, Ambinder R, Beschorner W E, Hayward G S, Mann R
Johns Hopkins Oncology Center, Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Maryland 21205.
Am J Clin Pathol. 1989 Jan;91(1):1-5. doi: 10.1093/ajcp/91.1.1.
A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.
通过Southern印迹法对总共151份未经选择的恶性和非恶性淋巴组织样本进行检测，以确定是否存在爱泼斯坦-巴尔病毒（EBV）DNA。28份霍奇金病（HD）样本中有8份（29%）可检测到EBV DNA。结节硬化型和混合细胞型组织学结果均为阳性。其次频率最高的肿瘤类型为弥漫性大细胞淋巴瘤，为8%。一些HD活检样本中存在EBV DNA表明，EBV可能是该疾病发病机制中的一个因素。或者，其存在可能继发于HD的免疫缺陷特征。在一些HD病例中报道的克隆性B淋巴细胞扩增可能是由EBV感染引起的。
