Gledhill S, Gallagher A, Jones D B, Krajewski A S, Alexander F E, Klee E, Wright D H, O'Brien C, Onions D E, Jarrett R F
Department of Veterinary Pathology, University of Glasgow, UK.
Br J Cancer. 1991 Aug;64(2):227-32. doi: 10.1038/bjc.1991.281.
Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtypes specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients.
对35例霍奇金淋巴瘤（HD）患者进行分析，检测其是否存在爱泼斯坦-巴尔病毒（EBV）和人类疱疹病毒6型（HHV-6）DNA。35例中有11例检测到EBV基因组，而所有病例中HHV-6均为阴性。随后，对10例EBV阳性病例使用病毒末端区域的探针进行分析；结果表明，EBV感染细胞呈克隆性扩增。采用EBV亚型特异性DNA扩增法证实，EBV阳性病例中存在的是A亚型而非B亚型。EBV阳性病例的年龄分布表明，随着年龄增长，阳性率增加具有统计学意义的显著趋势。这首次表明EBV与HD患者的任何亚组均存在显著关联。
