Si Yong-Ai, Yan Huan, Ni Wei, Liu Zhen-Hua, Lu Ting-Xiang, Cheng Chang-Xiang, Liu Hai-Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Nat Prod Bioprospect. 2014 Dec;4(6):315-8. doi: 10.1007/s13659-014-0043-1. Epub 2014 Nov 1.
Two new monosaccharide steroidal saponins, named ypsilandroside S (1) and ypsilandroside T (2), have been isolated from the whole plants of Ypsilandra thibetica. Their structures were elucidated as heloniogenin 3-O-β-D-apiofuranoside (1) and pregna 5,16-dien-3β,12α-diol-20-one-3-O-β-D-apiofuranoside (2) by spectroscopic techniques (1D and 2D NMR, MS). Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.
从西藏开口箭全草中分离得到了两种新的单糖甾体皂苷，命名为开口箭皂苷S（1）和开口箭皂苷T（2）。通过光谱技术（一维和二维核磁共振、质谱）确定它们的结构分别为海葱苷元3 - O - β - D - 芹菜呋喃糖苷（1）和孕甾-5,16 - 二烯-3β,12α - 二醇-20 - 酮-3 - O - β - D - 芹菜呋喃糖苷（2）。测试了化合物1和2对脂多糖诱导的RAW 264.7细胞中一氧化氮产生的抑制作用。
