Xie Bai-Bo, Liu Hai-Yang, Ni Wei, Chen Chang-Xiang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Steroids. 2009 Nov;74(12):950-5. doi: 10.1016/j.steroids.2009.07.001. Epub 2009 Jul 10.
A further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded one sapogenin and 12 spirostanol saponins. Five of these are new compounds, designated as ypsilandrosides C-G (2-6). Their structures were determined by detailed spectroscopic analysis, including extensive 1D and 2D NMR data, and by the result of a hydrolytic reaction. Compounds 2-5 were rare steroidal saponins that an apiofuranosyl unit was directly linked at C-3 of the aglycone. Selected spirostanol saponins (2-6, 9) were tested for their cytotoxic activities against K562, SPC-A-1, BGC-823, Eca-109, and AGS cell lines. Compounds 6 and 9 showed moderate inhibitory activity against all five cell lines. The antifungal properties of the new spirostanol saponins (2-6) against Candida albicans were also determined.
对西藏开口箭全草进行的进一步植物化学研究得到了一种皂苷元及12种螺旋甾烷醇皂苷。其中5种为新化合物，命名为开口箭皂苷C-G（2-6）。通过详细的光谱分析，包括大量的一维和二维核磁共振数据，以及水解反应结果确定了它们的结构。化合物2-5是罕见的甾体皂苷，其呋喃芹菜糖基单元直接连接在苷元的C-3位。对选定的螺旋甾烷醇皂苷（2-6、9）针对K562、SPC-A-1、BGC-823、Eca-109和AGS细胞系进行了细胞毒性活性测试。化合物6和9对所有5种细胞系均表现出中等抑制活性。还测定了新的螺旋甾烷醇皂苷（2-6）对白色念珠菌的抗真菌特性。
