Chen Yu, Si Yong-Ai, Ni Wei, Yan Huan, Qin Xu-Jie, Chen Chang-Xiang, Liu Hai-Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
University of Chinese Academy of Sciences, Beijing, 100039, China.
Nat Prod Bioprospect. 2016 Jun;6(3):173-82. doi: 10.1007/s13659-016-0098-2. Epub 2016 Apr 20.
Phytochemical investigation on the whole plants of Ypsilandra yunnanensis was carried out for the first time and led to the isolation of five new cholestanol glycosides, ypsiyunnosides A-E (1-5), and one known analogue. Their structures were determined mainly by detailed spectroscopic analysis, including extensive 1D and 2D NMR, MS and UV, as well as chemical methods. Among them, compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon, which was identified as (23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one. Their induced platelet aggregation activities and cytotoxicities were evaluated. Five new cholestanol glycosides, ypsiyunnosides A-E (1-5), were isolated from the whole plants of Ypsilandra yunnanensis. Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon. Their structures were elucidated by a combination of 1D and 2D NMR, MS and chemical analysis.
首次对云南开口箭全草进行了植物化学研究，从中分离得到5个新的胆甾烷醇苷，即云南开口箭苷A - E（1 - 5）以及1个已知类似物。它们的结构主要通过详细的光谱分析确定，包括广泛的一维和二维核磁共振、质谱和紫外光谱，以及化学方法。其中，化合物1具有罕见的6/6/6/5/5稠环胆甾烷醇骨架，被鉴定为(23R,25R)-3β,16α,26-三醇-16,23-环胆甾-5,17(20)-二烯-22-酮。对它们的诱导血小板聚集活性和细胞毒性进行了评估。从云南开口箭全草中分离得到5个新的胆甾烷醇苷，即云南开口箭苷A - E（1 - 5）。化合物1具有罕见的6/6/6/5/5稠环胆甾烷醇骨架。通过一维和二维核磁共振、质谱以及化学分析相结合的方法阐明了它们的结构。
