人体研究中富含共轭亚油酸（CLA）的食物及CLA补充剂与血脂水平的关联：一项系统评价和荟萃分析
Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis.
作者信息
Derakhshande-Rishehri Seyede-Masome, Mansourian Marjan, Kelishadi Roya, Heidari-Beni Motahar
机构信息
1Food Security Research Center,Department of Clinical Nutrition,School of Nutrition & Food Sciences,Isfahan University of Medical Sciences,Isfahan,Islamic Republic of Iran.
2Department of Biostatistics and Epidemiology,School of Health,Isfahan University of Medical Sciences,Isfahan,Islamic Republic of Iran.
出版信息
Public Health Nutr. 2015 Aug;18(11):2041-54. doi: 10.1017/S1368980014002262. Epub 2014 Nov 7.
OBJECTIVE
The present study aimed to review the association of conjugated linoleic acid (CLA) consumption in two forms, foods enriched in CLA and CLA supplements, with serum lipid profile in human studies.
DESIGN
Systematic review and meta-analysis.
SETTING
Search process was conducted in PubMed, Cochrane Library, Google Scholar, Scopus and Science Direct. Clinical trials that investigated the association of CLA intakes either in the form of supplements or enriched foods with lipid profile in healthy adults were included. All outcomes were recorded as continuous variables, and the effect size was measured by analysis of the mean and standard deviation before and after the intervention for case and control groups.
SUBJECTS
Healthy adult population.
RESULTS
CLA supplementation was associated with a significant decrease in LDL cholesterol (mean difference = -0.218; 95% CI -0.358, -0.077; P = 0.002), a non-significant decrease in HDL cholesterol (mean difference = -0.051; 95% CI -0.188, 0.086; P = 0.468), a non-significant increase in total cholesterol (mean difference = 0.009; 95% CI -0.128, 0.146; P = 0.896) and a non-significant decrease in TAG (mean difference = -0.065; 95% CI -0.20, 0.07; P = 0.344). Foods enriched with CLA were associated with significantly decreased LDL cholesterol (mean difference = -0.231; 95% CI -0.438, -0.024; P = 0.028), non-significantly increased HDL-C (mean difference = 0.075; 95% CI -0.121, 0.270; P=0.455), non-significantly decreased total cholesterol (mean difference = -0.158; 95% CI -0.349, 0.042; P = 0.124) and non-significantly decreased TAG (mean difference = -0.078; 95% CI -0.274, 0.117; P = 0.433).
CONCLUSIONS
According to our analysis, consumption of foods enriched with CLA or CLA supplements has favourable effects on LDL cholesterol levels.
目的
本研究旨在回顾人类研究中两种形式的共轭亚油酸（CLA）摄入，即富含CLA的食物和CLA补充剂，与血清脂质谱之间的关联。
设计
系统评价和荟萃分析。
设置
检索过程在PubMed、Cochrane图书馆、谷歌学术、Scopus和科学Direct中进行。纳入了调查补充剂或富含CLA的食物形式的CLA摄入量与健康成年人脂质谱之间关联的临床试验。所有结果均记录为连续变量，效应大小通过分析病例组和对照组干预前后的均值和标准差来衡量。
对象
健康成年人群。
结果
补充CLA与低密度脂蛋白胆固醇显著降低相关（平均差异=-0.218；95%可信区间-0.358，-0.077；P=0.002），高密度脂蛋白胆固醇无显著降低（平均差异=-0.051；95%可信区间-0.188，0.086；P=0.468），总胆固醇无显著升高（平均差异=0.009；95%可信区间-0.128，0.146；P=0.896），甘油三酯无显著降低（平均差异=-0.065；95%可信区间-0.20，0.07；P=0.344）。富含CLA的食物与低密度脂蛋白胆固醇显著降低相关（平均差异=-0.231；95%可信区间-0.438，-0.024；P=0.028），高密度脂蛋白胆固醇无显著升高（平均差异=0.075；95%可信区间-0.121，0.270；P=0.455），总胆固醇无显著降低（平均差异=-0.158；95%可信区间-0.349，0.042；P=0.124），甘油三酯无显著降低（平均差异=-0.078；95%可信区间-0.274，0.117；P=0.433）。
结论
根据我们的分析，食用富含CLA的食物或CLA补充剂对低密度脂蛋白胆固醇水平有有利影响。
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