Wang Sheng-Yuan, Wang Yu, Xie Fang-Qin, Li Yan-Xing, Wan Xue-Lian, Ma Wei-Wei, Wang De-Cai, Wu Yong-Hui
Int J Occup Environ Health. 2015;21(1):40-8. doi: 10.1179/2049396714Y.0000000088. Epub 2014 Nov 10.
Phthalates are environmental chemicals with reproductive toxicity and estrogenic effects in animals. They are of increasing concern to human health.
To determine whether phthalate levels in semen were associated with infertility.
Using semen samples from 107 infertile and 94 fertile men, the presence and quantity of five phthalate esters were measured using high-performance liquid chromatography (HPLC). Using data collected from questionnaires and clinical examinations, the correlation between phthalate exposure and semen quality was analyzed.
The cumulative levels of the measured phthalate esters were significantly higher in the infertility group compared to the control group (P<0·05). Concentrations of the five phthalate esters in men varied by age with older men showing higher cumulative levels.
The presence of phthalates may contribute to male infertility in our study population.
邻苯二甲酸盐是具有生殖毒性和对动物有雌激素效应的环境化学物质。它们日益引起人们对人类健康的关注。
确定精液中邻苯二甲酸盐水平是否与不育症有关。
使用107名不育男性和94名生育能力正常男性的精液样本，采用高效液相色谱法（HPLC）测量五种邻苯二甲酸酯的存在情况和含量。利用问卷调查和临床检查收集的数据，分析邻苯二甲酸盐暴露与精液质量之间的相关性。
与对照组相比，不育组中所测邻苯二甲酸酯的累积水平显著更高（P<0·05）。男性体内五种邻苯二甲酸酯的浓度随年龄而变化，年龄较大的男性显示出更高的累积水平。
在我们的研究人群中，邻苯二甲酸盐的存在可能导致男性不育。
