用于治疗马肌腱韧带损伤的再生医学。一系列150匹马接受了血小板衍生生长因子治疗。
Regenerative medicine for the treatment of Teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors.
作者信息
Scala Marco, Lenarduzzi Silvia, Spagnolo Francesco, Trapasso Maria, Ottonello Chiara, Muraglia Anita, Barla Annalisa, Squillario Margherita, Strada Paolo
机构信息
Department of Plastic and Reconstructive Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale Per La Ricerca Sul Cancro, Genova, Italy.
Department of Medical and Veterinary Sciences, University of Parma, Parma, Italy.
出版信息
In Vivo. 2014 Nov-Dec;28(6):1119-23.
BACKGROUND/AIM: The aim of the present study was to evaluate the safety and the clinical outcome of platelet-rich plasma for the treatment of teno-desmic injures in competition horses.
PATIENTS AND METHODS
From January 2009 to December 2011, 150 sport horses suffering from teno-desmic injuries were treated with no-gelled platelet-concentrate.
RESULTS
No horse showed any major adverse reaction as a result of the procedure. Full healing was obtained for 81% of the horses. Twelve percent had clinical improvement and only 7% a failure. Eight percent of cases of relapse were observed. No statistically significant correlation existed between clinical outcome and the area of the lesion. A statistically significant correlation existed between the clinical outcome and the age of the horse.
CONCLUSION
Treatment with platelet-derived growth factors leads to the formation of a tendon with normal morphology and functionality, which translate in the resumption of the agonistic activity for the horses we treated.
背景/目的：本研究旨在评估富血小板血浆治疗竞技用马匹腱-韧带损伤的安全性及临床疗效。
患者和方法
2009年1月至2011年12月，150匹患有腱-韧带损伤的运动马匹接受了未凝胶化的血小板浓缩液治疗。
结果
没有马匹因该治疗出现任何严重不良反应。81%的马匹完全愈合。12%有临床改善，仅7%治疗失败。观察到8%的病例复发。临床疗效与损伤面积之间不存在统计学显著相关性。临床疗效与马匹年龄之间存在统计学显著相关性。
结论
血小板衍生生长因子治疗可导致形成形态和功能正常的肌腱，这使得我们治疗的马匹恢复了竞技活动。
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