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A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence.

作者信息

Saffer J D, Thurston S J

机构信息

Jackson Laboratory, Bar Harbor, Maine 04609.

出版信息

Mol Cell Biol. 1989 Feb;9(2):355-64. doi: 10.1128/mcb.9.2.355-364.1989.

DOI:10.1128/mcb.9.2.355-364.1989
PMID:2540418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362609/
Abstract

A negative regulatory element has been found within a member of the African green monkey Alu family of interspersed repeated sequences. This "reducer" element decreased transcription in both directions from a cellular simian virus 40-like bidirectional promoter independently of both orientation and position. The reducer was not promoter specific since it also decreased expression from the simian virus 40 early and human beta-globin promoters. In addition, the reducer decreased transcription from a polymerase III promoter. The reducer was contained in 38 base pairs of an Alu family member and interacted specifically with a monkey cell nuclear protein.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/96902919477d/molcellb00050-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/ca47c7b238f3/molcellb00050-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/daaf277f91d4/molcellb00050-0012-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/52dbce26c211/molcellb00050-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/b821fbd71e00/molcellb00050-0013-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/5f4503c09347/molcellb00050-0015-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/96902919477d/molcellb00050-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/ca47c7b238f3/molcellb00050-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/daaf277f91d4/molcellb00050-0012-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/52dbce26c211/molcellb00050-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/b821fbd71e00/molcellb00050-0013-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/5f4503c09347/molcellb00050-0015-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/940b/362609/96902919477d/molcellb00050-0016-a.jpg

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A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence.
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本文引用的文献

1
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.筛选表达编码黄嘌呤 - 鸟嘌呤磷酸核糖转移酶的大肠杆菌基因的动物细胞。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2072-6. doi: 10.1073/pnas.78.4.2072.
2
Unusual class of Alu sequences containing a potential Z-DNA segment.一类含有潜在Z-DNA片段的异常Alu序列。
Mol Cell Biol. 1983 May;3(5):960-4. doi: 10.1128/mcb.3.5.960-964.1983.
3
Gene regulation: repression of activators.
基因的空间组织作为调控表达的一个组成部分。
Chromosoma. 2010 Feb;119(1):13-25. doi: 10.1007/s00412-009-0236-2. Epub 2009 Aug 30.
4
A CBF5 mutation that disrupts nucleolar localization of early tRNA biosynthesis in yeast also suppresses tRNA gene-mediated transcriptional silencing.破坏酵母早期tRNA生物合成的核仁定位的CBF5突变也抑制了tRNA基因介导的转录沉默。
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13108-13. doi: 10.1073/pnas.240454997.
5
Bovine alpha s1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice.牛αs1-酪蛋白基因序列指导人粒细胞-巨噬细胞集落刺激因子在转基因小鼠乳汁中高水平表达。
Transgenic Res. 1997 Jan;6(1):75-84. doi: 10.1023/a:1018461201385.
6
A novel family of repeat sequences in the mouse genome responsive to retinoic acid.小鼠基因组中一个对视黄酸有反应的新型重复序列家族。
Mamm Genome. 1996 Oct;7(10):741-8. doi: 10.1007/s003359900224.
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Increased concentration of some transcription factor binding sites in human retroposons of the Alu family.人类Alu家族反转座子中某些转录因子结合位点的浓度增加。
Genetica. 1996 Jan;97(1):15-22. doi: 10.1007/BF00132576.
8
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Regulation of a human cytomegalovirus immediate-early gene (US3) by a silencer-enhancer combination.人巨细胞病毒立即早期基因（US3）受沉默子-增强子组合调控。
J Virol. 1996 Jan;70(1):91-100. doi: 10.1128/JVI.70.1.91-100.1996.
10
Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element.一段与小鼠B1重复元件同源的短序列对免疫球蛋白κ轻链基因转录的负调控
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4
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7
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