Hlavová H
Cesk Epidemiol Mikrobiol Imunol. 1989 Mar;38(2):74-81.
In 1974-1987 at the virological department of the Regional Hygiene Station in Brno viruses from the group coxsackie A were isolated in 67 patients, in particular on newborn mice, and exceptionally in tissue cultures. Because typing sera were not available, it was not possible with the exception of coxsackie A9 to differentiate different serotypes. The aetiological relationship of the isolated virus and the disease was evaluated according to commonly accepted criteria. The infection was manifested clinically above all by affection of the nervous system--in 43 patients, i.e. 64.17%--most frequently as aseptic meningitis. The second most frequent disease were herpanginas. The group of coxsackie A viruses also played an aetiological role in diseases of the respiratory and digestive tract, in hand, foot and mouth disease. The disease took a benign course, only in a 7-day-old neonate it caused fatal haemorrhagic pneumonia. Infections caused by coxsackie A viruses occurred mostly in the summer and autumn months, sporadically or epidemically in child communities. In the population aged 0-15 years with the highest incidence in the group aged 0-5 years, mainly in boys.
1974年至1987年期间，布尔诺地区卫生防疫站病毒学部门从67名患者身上分离出柯萨奇A组病毒，特别是从新生小鼠体内分离得到，偶尔也从组织培养物中分离得到。由于没有分型血清，除柯萨奇A9外，无法区分不同血清型。根据普遍接受的标准评估分离出的病毒与疾病的病因关系。该感染在临床上主要表现为神经系统受累——43例患者（即64.17%）出现这种情况，最常见的是无菌性脑膜炎。第二常见的疾病是疱疹性咽峡炎。柯萨奇A组病毒在呼吸道和消化道疾病、手足口病中也起到病因作用。疾病呈良性病程，仅在一名7日龄新生儿中导致致命性出血性肺炎。柯萨奇A组病毒引起的感染大多发生在夏季和秋季，在儿童群体中呈散发性或流行性。在0至15岁人群中发病率最高，其中0至5岁组最高，主要为男孩。
