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血管网络中的缺氧:一种解开糖尿病悖论的复杂系统方法。

Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox.

作者信息

Gandica Yérali, Schwarz Tobias, Oliveira Orlando, Travasso Rui D M

机构信息

Center for Computational Physics, Department of Physics, University of Coimbra, Coimbra, Portugal.

Center for Computational Physics, Department of Physics, University of Coimbra, Coimbra, Portugal; Heinz-Brandt-Schule, Berlin, Germany.

出版信息

PLoS One. 2014 Nov 19;9(11):e113165. doi: 10.1371/journal.pone.0113165. eCollection 2014.

Abstract

In this work we model the extent of hypoxia in the diabetic retina as a function of the area affected by vessel disruption. We find two regimes that differ on the ratio between the area of disrupted vasculature and the area of tissue in hypoxia. In the first regime the hypoxia is localized in the vicinity of the vascular disruption, while in the second regime there is a generalized hypoxia in the affected tissue. The transition between these two regimes occurs when the tissue area affected by individual sites of vessel damage is on the order of the square of the characteristic irrigation length in the tissue (the maximum distance that an irrigated point in the tissue is from an existing vessel). We observe that very high levels of hypoxia are correlated with the rupture of larger vessels in the retina, and with smaller radii of individual sites of vessel damage. Based on this property of vascular networks, we propose a novel mechanism for the transition between the nonproliferative and the proliferative stages in diabetic retinopathy.

摘要

在这项工作中,我们将糖尿病视网膜中的缺氧程度建模为血管破坏所影响区域的函数。我们发现两种情况,它们在血管受损区域与缺氧组织区域的比例上有所不同。在第一种情况下,缺氧局限于血管破坏附近,而在第二种情况下,受影响组织中存在全身性缺氧。当受单个血管损伤部位影响的组织面积约为组织中特征性灌注长度(组织中一个被灌注点到现有血管的最大距离)的平方时,这两种情况之间会发生转变。我们观察到,非常高的缺氧水平与视网膜中较大血管的破裂以及单个血管损伤部位的较小半径相关。基于血管网络的这一特性,我们提出了一种糖尿病视网膜病变中非增殖期和增殖期之间转变的新机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4308/4237512/bcab6441e5e8/pone.0113165.g001.jpg

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