Bilodeau Elizabeth A, Prasad Joanne L, Alawi Faizan, Seethala Raja R
Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, 15261, USA,
Head Neck Pathol. 2014 Dec;8(4):400-10. doi: 10.1007/s12105-014-0588-7. Epub 2014 Nov 20.
In this article we outline the molecular findings of select odontogenic tumors. In each section, we briefly review selected the clinicoradiographic, histologic, immunologic features, focusing on the molecular findings and their applications in practice. The understanding of molecular pathobiology at various other organ sites has developed quite rapidly in recent years, however much remains unknown about the genetic profile of odontogenic tumors. Improved understanding of mutations in odontogenic tumors may clarify classification schema and elucidate targets for novel therapies. Molecular testing will no doubt improve our understanding of odontogenic tumor pathogenesis and will likely be, someday, an important component of routine clinical practice and its role will only increase in the coming years.
在本文中，我们概述了特定牙源性肿瘤的分子研究结果。在每个章节中，我们简要回顾了所选的临床影像学、组织学、免疫学特征，重点关注分子研究结果及其在实际应用中的情况。近年来，对其他各个器官部位分子病理生物学的认识发展迅速，然而，关于牙源性肿瘤的基因图谱仍有许多未知之处。对牙源性肿瘤突变的进一步了解可能会澄清分类方案，并阐明新疗法的靶点。分子检测无疑将增进我们对牙源性肿瘤发病机制的理解，并且在未来的某一天很可能会成为常规临床实践的重要组成部分，其作用在未来几年只会不断增强。
